FBXW8

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F-box and WD repeat domain containing 8
Identifiers
Symbol(s) FBXW8; FBW6; FBW8; FBX29; FBXO29; MGC33534
External IDs OMIM: 609073 MGI: 1923041 HomoloGene: 17731
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 26259 231672
Ensembl ENSG00000174989 ENSMUSG00000032867
Uniprot Q8N3Y1 Q3TQ22
Refseq NM_012174 (mRNA)
NP_036306 (protein)		 NM_172721 (mRNA)
NP_766309 (protein)
Location Chr 12: 115.83 - 115.95 Mb Chr 5: 118.33 - 118.42 Mb
Pubmed search [1] [2]

F-box and WD repeat domain containing 8, also known as FBXW8, is a human gene.[1]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: FBXW8 F-box and WD repeat domain containing 8.

[edit] Further reading

  • Tsutsumi T, Kuwabara H, Arai T, et al. (2008). "Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.". Mol. Cell. Biol. 28 (2): 743-51. doi:10.1128/MCB.01665-07. PMID 17998335. 
  • Koch HB, Zhang R, Verdoodt B, et al. (2007). "Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.". Cell Cycle 6 (2): 205-17. PMID 17314511. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Watanabe N, Arai H, Nishihara Y, et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419-24. doi:10.1073/pnas.0307700101. PMID 15070733. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Dias DC, Dolios G, Wang R, Pan ZQ (2003). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601-6. doi:10.1073/pnas.252646399. PMID 12481031. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180-2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. 
  • Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177-9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
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