FBXO4

From Wikipedia, the free encyclopedia

F-box protein 4

Identifiers

FBXO4; DKFZp547N213; FBX4; FLJ10141

External IDs

OMIM: 609090 MGI: 2146220 HomoloGene: 8134

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding
Cellular Component:	• ubiquitin ligase complex
Biological Process:	• protein ubiquitination

Orthologs

Human

Mouse

Refseq

NM_012176 (mRNA)
NP_036308 (protein)

NM_134099 (mRNA)
NP_598860 (protein)

Location

Chr 5: 41.96 - 41.98 Mb

Chr 15: 3.92 - 3.93 Mb

Pubmed search

[1]

[2]

F-box protein 4, also known as FBXO4, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: FBXO4 F-box protein 4.

[edit] Further reading

Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177-9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180-2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Chiaur DS, Murthy S, Cenciarelli C, et al. (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors.". Cytogenet. Cell Genet. 88 (3-4): 255-8. PMID 10828603.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins.". Genes Dev. 18 (21): 2573-80. doi:10.1101/gad.1255304. PMID 15520277.
Lee TH, Perrem K, Harper JW, et al. (2006). "The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance.". J. Biol. Chem. 281 (2): 759-68. doi:10.1074/jbc.M509855200. PMID 16275645.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Liu Y, Hedvat CV, Mao S, et al. (2006). "The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.". Mol. Cell. Biol. 26 (8): 3114-23. doi:10.1128/MCB.26.8.3114-3123.2006. PMID 16581786.
Lin DI, Barbash O, Kumar KG, et al. (2006). "Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.". Mol. Cell 24 (3): 355-66. doi:10.1016/j.molcel.2006.09.007. PMID 17081987.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.