FBXL5

From Wikipedia, the free encyclopedia

F-box and leucine-rich repeat protein 5

Identifiers

FBXL5; FBL4; FBL5; FLR1

External IDs

OMIM: 605655 MGI: 2152883 HomoloGene: 8129

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding
Cellular Component:	• ubiquitin ligase complex
Biological Process:	• protein ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012161 (mRNA)
NP_036293 (protein)

NM_178729 (mRNA)
NP_848844 (protein)

Location

Chr 4: 15.22 - 15.27 Mb

Chr 5: 44.03 - 44.07 Mb

Pubmed search

[1]

[2]

F-box and leucine-rich repeat protein 5, also known as FBXL5, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177-9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180-2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (2001). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family.". Genomics 67 (1): 40-7. doi:10.1006/geno.2000.6211. PMID 10945468.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Zhang N, Liu J, Ding X, et al. (2007). "FBXL5 interacts with p150Glued and regulates its ubiquitination.". Biochem. Biophys. Res. Commun. 359 (1): 34-9. doi:10.1016/j.bbrc.2007.05.068. PMID 17532294.