Far upstream element-binding protein 1

From Wikipedia, the free encyclopedia

Far upstream element (FUSE) binding protein 1

PDB rendering based on 1j4w.

Available structures: 1j4w, 1x4m, 1x4n

Identifiers

Symbol(s)

FUBP1; FBP; FUBP

External IDs

OMIM: 603444 MGI: 1196294 HomoloGene: 48253

Gene ontology
Molecular Function:	• single-stranded DNA binding • transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003902 (mRNA)
NP_003893 (protein)

NM_057172 (mRNA)
NP_476513 (protein)

Location

Chr 1: 78.18 - 78.22 Mb

Chr 3: 152.15 - 152.17 Mb

Pubmed search

[1]

[2]

Far upstream element (FUSE) binding protein 1, also known as FUBP1, is a human gene.^[1]

This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.^[1]

[edit] References

^ ^a ^b Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1.

[edit] Further reading

Duncan R, Bazar L, Michelotti G, et al. (1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif.". Genes Dev. 8 (4): 465-80. PMID 8125259.
Williams BY, Hamilton SL, Sarkar HK (2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain.". FEBS Lett. 470 (2): 207-10. PMID 10734235.
Liu J, He L, Collins I, et al. (2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription.". Mol. Cell 5 (2): 331-41. PMID 10882074.
Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.". Mol. Cell. Biol. 20 (20): 7463-79. PMID 11003644.
He L, Weber A, Levens D (2000). "Nuclear targeting determinants of the far upstream element binding protein, a c-myc transcription factor.". Nucleic Acids Res. 28 (22): 4558-65. PMID 11071946.
Vindigni A, Ochem A, Triolo G, Falaschi A (2001). "Identification of human DNA helicase V with the far upstream element-binding protein.". Nucleic Acids Res. 29 (5): 1061-7. PMID 11222755.
Liu J, Akoulitchev S, Weber A, et al. (2001). "Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.". Cell 104 (3): 353-63. PMID 11239393.
Braddock DT, Louis JM, Baber JL, et al. (2002). "Structure and dynamics of KH domains from FBP bound to single-stranded DNA.". Nature 415 (6875): 1051-6. doi:10.1038/4151051a. PMID 11875576.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome.". Genome Res. 12 (8): 1231-45. doi:10.1101/gr.473902. PMID 12176931.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation.". Nat. Genet. 34 (3): 330-6. doi:10.1038/ng1182. PMID 12819782.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kouzine F, Liu J, Sanford S, et al. (2004). "The dynamic response of upstream DNA to transcription-generated torsional stress.". Nat. Struct. Mol. Biol. 11 (11): 1092-100. doi:10.1038/nsmb848. PMID 15502847.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork.". Exp. Eye Res. 82 (6): 1046-52. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
Liu J, Kouzine F, Nie Z, et al. (2006). "The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression.". EMBO J. 25 (10): 2119-30. doi:10.1038/sj.emboj.7601101. PMID 16628215.
Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.". J. Biol. Chem. 281 (24): 16193-6. doi:10.1074/jbc.C600041200. PMID 16672220.