FANCL

From Wikipedia, the free encyclopedia

Fanconi anemia, complementation group L

Identifiers

FANCL; FLJ10335; PHF9; POG

External IDs

OMIM: 608111 MGI: 1914280 HomoloGene: 9987

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• nucleus • nuclear envelope
Biological Process:	• DNA repair • ubiquitin cycle • gamete generation • regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018062 (mRNA)
NP_060532 (protein)

XM_977417 (mRNA)
XP_982511 (protein)

Location

Chr 2: 58.24 - 58.32 Mb

Chr 11: 26.29 - 26.37 Mb

Pubmed search

[1]

[2]

Fanconi anemia, complementation group L, also known as FANCL, is a human gene.^[1]

[edit] References

^ Entrez Gene: FANCL Fanconi anemia, complementation group L.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Agoulnik AI, Lu B, Zhu Q, et al. (2003). "A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd.". Hum. Mol. Genet. 11 (24): 3047–53. PMID 12417526.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lu B, Bishop CE (2003). "Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis.". J. Biol. Chem. 278 (18): 16289–96. doi:10.1074/jbc.M211023200. PMID 12574169.
Lu B, Bishop CE (2004). "Late onset of spermatogenesis and gain of fertility in POG-deficient mice indicate that POG is not necessary for the proliferation of spermatogonia.". Biol. Reprod. 69 (1): 161–8. doi:10.1095/biolreprod.102.014654. PMID 12606378.
Meetei AR, Sechi S, Wallisch M, et al. (2003). "A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.". Mol. Cell. Biol. 23 (10): 3417–26. PMID 12724401.
Meetei AR, de Winter JP, Medhurst AL, et al. (2003). "A novel ubiquitin ligase is deficient in Fanconi anemia.". Nat. Genet. 35 (2): 165–70. doi:10.1038/ng1241. PMID 12973351.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Meetei AR, Levitus M, Xue Y, et al. (2004). "X-linked inheritance of Fanconi anemia complementation group B.". Nat. Genet. 36 (11): 1219–24. doi:10.1038/ng1458. PMID 15502827.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Meetei AR, Medhurst AL, Ling C, et al. (2005). "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.". Nat. Genet. 37 (9): 958–63. doi:10.1038/ng1626. PMID 16116422.
Gurtan AM, Stuckert P, D'Andrea AD (2006). "The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.". J. Biol. Chem. 281 (16): 10896–905. doi:10.1074/jbc.M511411200. PMID 16474167.
Zhang J, Wang X, Lin CJ, et al. (2007). "Altered expression of FANCL confers mitomycin C sensitivity in Calu-6 lung cancer cells.". Cancer Biol. Ther. 5 (12): 1632–6. PMID 17106252.