FANCF

From Wikipedia, the free encyclopedia

Fanconi anemia, complementation group F

PDB rendering based on 2iqc.

Available structures: 2iqc

Identifiers

Symbol(s)

FANCF; FAF; MGC126856

External IDs

OMIM: 603467 HomoloGene: 75185

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• cellular_component • nucleus
Biological Process:	• DNA repair • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_022725 (mRNA)
NP_073562 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 11: 22.6 - 22.6 Mb

n/a

Pubmed search

[1]

n/a

Fanconi anemia, complementation group F, also known as FANCF, is a human gene.^[1]

[edit] References

^ Entrez Gene: FANCF Fanconi anemia, complementation group F.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Joenje H, Oostra AB, Wijker M, et al. (1997). "Evidence for at least eight Fanconi anemia genes.". Am. J. Hum. Genet. 61 (4): 940–4. PMID 9382107.
de Winter JP, Rooimans MA, van Der Weel L, et al. (2000). "The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM.". Nat. Genet. 24 (1): 15–6. doi:10.1038/71626. PMID 10615118.
de Winter JP, van der Weel L, de Groot J, et al. (2000). "The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG.". Hum. Mol. Genet. 9 (18): 2665–74. PMID 11063725.
Medhurst AL, Huber PA, Waisfisz Q, et al. (2001). "Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway.". Hum. Mol. Genet. 10 (4): 423–9. PMID 11157805.
Pace P, Johnson M, Tan WM, et al. (2002). "FANCE: the link between Fanconi anaemia complex assembly and activity.". EMBO J. 21 (13): 3414–23. doi:10.1093/emboj/cdf355. PMID 12093742.
Taniguchi T, D'Andrea AD (2002). "The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC.". Blood 100 (7): 2457–62. doi:10.1182/blood-2002-03-0860. PMID 12239156.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gordon SM, Buchwald M (2003). "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems.". Blood 102 (1): 136–41. doi:10.1182/blood-2002-11-3517. PMID 12649160.
Meetei AR, Sechi S, Wallisch M, et al. (2003). "A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.". Mol. Cell. Biol. 23 (10): 3417–26. PMID 12724401.
Meetei AR, de Winter JP, Medhurst AL, et al. (2003). "A novel ubiquitin ligase is deficient in Fanconi anemia.". Nat. Genet. 35 (2): 165–70. doi:10.1038/ng1241. PMID 12973351.
Marsit CJ, Liu M, Nelson HH, et al. (2004). "Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival.". Oncogene 23 (4): 1000–4. doi:10.1038/sj.onc.1207256. PMID 14647419.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMID 15124103.
Narayan G, Arias-Pulido H, Nandula SV, et al. (2004). "Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer.". Cancer Res. 64 (9): 2994–7. PMID 15126331.
Léveillé F, Blom E, Medhurst AL, et al. (2004). "The Fanconi anemia gene product FANCF is a flexible adaptor protein.". J. Biol. Chem. 279 (38): 39421–30. doi:10.1074/jbc.M407034200. PMID 15262960.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Meetei AR, Levitus M, Xue Y, et al. (2004). "X-linked inheritance of Fanconi anemia complementation group B.". Nat. Genet. 36 (11): 1219–24. doi:10.1038/ng1458. PMID 15502827.
Meetei AR, Medhurst AL, Ling C, et al. (2005). "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.". Nat. Genet. 37 (9): 958–63. doi:10.1038/ng1626. PMID 16116422.