FAM19A5

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Family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
Identifiers
Symbol(s) FAM19A5; QLLK5208; TAFA-5; TAFA5; UNQ5208
External IDs MGI: 2146182 HomoloGene: 22888
Orthologs
Human Mouse
Entrez 25817 106014
Ensembl n/a ENSMUSG00000054863
Uniprot n/a Q91WE9
Refseq NM_015381 (mRNA)
NP_056196 (protein)		 NM_134096 (mRNA)
NP_598857 (protein)
Location n/a Chr 15: 87.45 - 87.55 Mb
Pubmed search [1] [2]

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A5, also known as FAM19A5, is a human gene.[1]

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells.[1]

[edit] References

  1. ^ a b Entrez Gene: FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5.

[edit] Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Tom Tang Y, Emtage P, Funk WD, et al. (2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain.". Genomics 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
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