EYA2

From Wikipedia, the free encyclopedia

Eyes absent homolog 2 (Drosophila)

Identifiers

EYA2; EAB1; MGC10614

External IDs

OMIM: 601654 MGI: 109341 HomoloGene: 40711

Gene ontology
Molecular Function:	• magnesium ion binding • catalytic activity • phosphoprotein phosphatase activity • protein tyrosine phosphatase activity • hydrolase activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • multicellular organismal development • mesodermal cell fate specification • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005244 (mRNA)
NP_005235 (protein)

NM_010165 (mRNA)
NP_034295 (protein)

Location

Chr 20: 44.96 - 45.25 Mb

Chr 2: 165.32 - 165.46 Mb

Pubmed search

[1]

[2]

Eyes absent homolog 2 (Drosophila), also known as EYA2, is a human gene.^[1]

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Five transcript variants encoding three distinct isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: EYA2 eyes absent homolog 2 (Drosophila).

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Abdelhak S, Kalatzis V, Heilig R, et al. (1997). "A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.". Nat. Genet. 15 (2): 157–64. doi:10.1038/ng0297-157. PMID 9020840.
Zimmerman JE, Bui QT, Steingrímsson E, et al. (1997). "Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.". Genome Res. 7 (2): 128–41. PMID 9049631.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Duncan MK, Kos L, Jenkins NA, et al. (1997). "Eyes absent: a gene family found in several metazoan phyla.". Mamm. Genome 8 (7): 479–85. PMID 9195991.
Borsani G, DeGrandi A, Ballabio A, et al. (1999). "EYA4, a novel vertebrate gene related to Drosophila eyes absent.". Hum. Mol. Genet. 8 (1): 11–23. PMID 9887327.
Fan X, Brass LF, Poncz M, et al. (2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins.". J. Biol. Chem. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Fee BE, Doyle CA, Cleveland JL (2002). "A novel Eyes Absent 2 protein is expressed in the human eye.". Gene 285 (1-2): 221–8. PMID 12039049.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fougerousse F, Durand M, Lopez S, et al. (2003). "Six and Eya expression during human somitogenesis and MyoD gene family activation.". J. Muscle Res. Cell. Motil. 23 (3): 255–64. PMID 12500905.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang L, Yang N, Huang J, et al. (2005). "Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth.". Cancer Res. 65 (3): 925–32. PMID 15705892.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.