Exosome component 9

From Wikipedia, the free encyclopedia

Exosome component 9

PDB rendering based on 2nn6.

Available structures: 2nn6

Identifiers

Symbol(s)

EXOSC9; PM/Scl-75; PMSCL1; RRP45; Rrp45p; p5; p6

External IDs

OMIM: 606180 MGI: 1355319 HomoloGene: 3693

Gene ontology
Molecular Function:	• 3'-5'-exoribonuclease activity • RNA binding • exonuclease activity • protein binding • hydrolase activity
Cellular Component:	• nuclear exosome (RNase complex) • nucleus • nucleolus
Biological Process:	• rRNA processing • RNA processing • immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001034194 (mRNA)
NP_001029366 (protein)

NM_019393 (mRNA)
NP_062266 (protein)

Location

Chr 4: 122.94 - 122.96 Mb

n/a

Pubmed search

[1]

[2]

Exosome component 9, also known as EXOSC9, is a human gene.^[1]

[edit] References

^ Entrez Gene: EXOSC9 exosome component 9.

[edit] Further reading

Alderuccio F, Chan EK, Tan EM (1991). "Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex.". J. Exp. Med. 173 (4): 941–52. PMID 2007859.
Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.". Genes Dev. 13 (16): 2148–58. PMID 10465791.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. PMID 11719186.
Mukherjee D, Gao M, O'Connor JP, et al. (2002). "The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements.". EMBO J. 21 (1-2): 165–74. doi:10.1093/emboj/21.1.165. PMID 11782436.
Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits.". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.". Arthritis Res. 4 (2): 134–8. PMID 11879549.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653–63. PMID 12419256.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2003). "The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus.". J. Biol. Chem. 278 (33): 30698–704. doi:10.1074/jbc.M302488200. PMID 12788944.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. PMID 14667819.
Raijmakers R, Renz M, Wiemann C, et al. (2004). "PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome.". Arthritis Rheum. 50 (2): 565–9. doi:10.1002/art.20056. PMID 14872500.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.". Genomics 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
van Dijk EL, Schilders G, Pruijn GJ (2007). "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.". RNA 13 (7): 1027–35. doi:10.1261/rna.575107. PMID 17545563.