Exosome component 7

From Wikipedia, the free encyclopedia

Exosome component 7

PDB rendering based on 2nn6.

Available structures: 2nn6

Identifiers

Symbol(s)

EXOSC7; EAP1; FLJ26543; KIAA0116; RRP42; Rrp42p; hRrp42p; p8

External IDs

OMIM: 606488 MGI: 1913696 HomoloGene: 8994

Gene ontology
Molecular Function:	• 3'-5'-exoribonuclease activity • RNA binding • exonuclease activity • protein binding • hydrolase activity
Cellular Component:	• exosome (RNase complex) • nucleus
Biological Process:	• rRNA processing • RNA catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015004 (mRNA)
NP_055819 (protein)

XM_001000053 (mRNA)
XP_001000053 (protein)

Location

Chr 3: 44.99 - 45.03 Mb

Chr 9: 122.96 - 122.98 Mb

Pubmed search

[1]

[2]

Exosome component 7, also known as EXOSC7, is a human gene.^[1]

[edit] References

^ Entrez Gene: EXOSC7 exosome component 7.

[edit] Further reading

Butler JS (2002). "The yin and yang of the exosome.". Trends Cell Biol. 12 (2): 90–6. PMID 11849973.
Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. PMID 7788527.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. PMID 11719186.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits.". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.". Arthritis Res. 4 (2): 134–8. PMID 11879549.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653–63. PMID 12419256.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.