Exosome component 2

From Wikipedia, the free encyclopedia

Exosome component 2

PDB rendering based on 2nn6.

Available structures: 2nn6

Identifiers

Symbol(s)

EXOSC2; RRP4; Rrp4p; hRrp4p; p7

External IDs

OMIM: 602238 MGI: 2385133 HomoloGene: 6095

Gene ontology
Molecular Function:	• 3'-5'-exoribonuclease activity • exonuclease activity • protein binding • 7S RNA binding • hydrolase activity
Cellular Component:	• exosome (RNase complex) • nucleus • cytoplasm
Biological Process:	• rRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014285 (mRNA)
NP_055100 (protein)

XM_979843 (mRNA)
XP_984937 (protein)

Location

Chr 9: 132.56 - 132.57 Mb

Chr 2: 31.49 - 31.5 Mb

Pubmed search

[1]

[2]

Exosome component 2, also known as EXOSC2, is a human gene.^[1]

[edit] References

^ Entrez Gene: EXOSC2 exosome component 2.

[edit] Further reading

Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes.". Nature 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749.
Morris CM, Heisterkamp N, Groffen J, Fitzgerald PH (1991). "Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia.". Blood 78 (4): 1078–84. PMID 1868241.
Zhu QS, Heisterkamp N, Groffen J (1990). "Characterization of the human ABL promoter regions.". Oncogene 5 (6): 885–91. PMID 2163052.
Soekarman D, van Denderen J, Hoefsloot L, et al. (1990). "A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia.". Leukemia 4 (6): 397–403. PMID 2193202.
Chen SJ, Chen Z, Font MP, et al. (1989). "Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation.". Nucleic Acids Res. 17 (19): 7631–42. PMID 2678002.
Heisterkamp N, Stam K, Groffen J, et al. (1985). "Structural organization of the bcr gene and its role in the Ph' translocation.". Nature 315 (6022): 758–61. PMID 2989703.
Shtivelman E, Lifshitz B, Gale RP, et al. (1986). "Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.". Cell 47 (2): 277–84. PMID 3021337.
Grosveld G, Verwoerd T, van Agthoven T, et al. (1987). "The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript.". Mol. Cell. Biol. 6 (2): 607–16. PMID 3023859.
Bernards A, Rubin CM, Westbrook CA, et al. (1987). "The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia.". Mol. Cell. Biol. 7 (9): 3231–6. PMID 3313010.
Groffen J, Heisterkamp N, Grosveld F, et al. (1982). "Isolation of human oncogene sequences (v-fes homolog) from a cosmid library.". Science 216 (4550): 1136–8. PMID 6281890.
Heisterkamp N, Groffen J, Stephenson JR (1983). "The human v-abl cellular homologue.". J. Mol. Appl. Genet. 2 (1): 57–68. PMID 6302194.
Heisterkamp N, Stephenson JR, Groffen J, et al. (1984). "Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia.". Nature 306 (5940): 239–42. PMID 6316147.
Groffen J, Stephenson JR, Heisterkamp N, et al. (1984). "Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22.". Cell 36 (1): 93–9. PMID 6319012.
Chissoe SL, Bodenteich A, Wang YF, et al. (1995). "Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.". Genomics 27 (1): 67–82. PMID 7665185.
Litz CE, McClure JS, Copenhaver CM, Brunning RD (1993). "Duplication of small segments within the major breakpoint cluster region in chronic myelogenous leukemia.". Blood 81 (6): 1567–72. PMID 8453102.
Mitchell P, Petfalski E, Tollervey D (1996). "The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.". Genes Dev. 10 (4): 502–13. PMID 8600032.
Mitchell P, Petfalski E, Shevchenko A, et al. (1997). "The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases.". Cell 91 (4): 457–66. PMID 9390555.
Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.". Genes Dev. 13 (16): 2148–58. PMID 10465791.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. PMID 11719186.