Exopolyphosphatase

From Wikipedia, the free encyclopedia

In enzymology, an exopolyphosphatase (EC 3.6.1.11) is an enzyme that catalyzes the chemical reaction

(polyphosphate)n + H₂O $\rightleftharpoons$ (polyphosphate)n-1 + phosphate

Thus, the two substrates of this enzyme are (polyphosphate)n and H₂O, whereas its two products are (polyphosphate)n-1 and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is polyphosphate phosphohydrolase. Other names in common use include metaphosphatase, acid phosphoanhydride phosphohydrolase, and Gra-Pase. This enzyme participates in purine metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1T6C, 1T6D, 1U6Z, and 2FLO.

[edit] References

IUBMB entry for 3.6.1.11
BRENDA references for 3.6.1.11 (Recommended.)
PubMed references for 3.6.1.11
PubMed Central references for 3.6.1.11
Google Scholar references for 3.6.1.11
Grossman D and Lang K (1962). "Anorganische Poly- und Metaphosphatasen sowie Polyphosphate im tierischen Zellkern". Biochem. Z. 336: 351–370.
Krishman PS (1952). "Apyrase, pyrophosphatase and metaphosphatase of Penicillium chrysogenum". Arch. Biochem. Biophys. 37: 224–234. doi:10.1016/0003-9861(52)90180-X.
Malmgren H (1952). "Enzymatic behavior of polymetaphosphate. V. Purification and specificity of the enzyme". Acta Chem. Scand. 6: 16–26.