EVL

From Wikipedia, the free encyclopedia

Enah/Vasp-like

PDB rendering based on 1qc6.

Available structures: 1qc6

Identifiers

Symbol(s)

EVL; RNB6

External IDs

MGI: 1194884 HomoloGene: 56752

Gene ontology
Molecular Function:	• actin binding • profilin binding • SH3 domain binding
Cellular Component:	• cytoplasm • cytoskeleton • focal adhesion • lamellipodium
Biological Process:	• actin filament organization • cell surface receptor linked signal transduction • nervous system development • axon guidance • actin polymerization and/or depolymerization • organ morphogenesis • actin filament-based movement • platelet activation • actin nucleation • barbed-end actin filament capping

Orthologs

Human

Mouse

Refseq

NM_016337 (mRNA)
NP_057421 (protein)

XM_979244 (mRNA)
XP_984338 (protein)

Location

Chr 14: 99.6 - 99.68 Mb

Chr 12: 109 - 109.14 Mb

Pubmed search

[1]

[2]

Enah/Vasp-like, also known as EVL, is a human gene.^[1]

[edit] References

^ Entrez Gene: EVL Enah/Vasp-like.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Ohta S, Mineta T, Kimoto M, Tabuchi K (1997). "Differential display cloning of a novel rat cDNA (RNB6) that shows high expression in the neonatal brain revealed a member of Ena/VASP family.". Biochem. Biophys. Res. Commun. 237 (2): 307-12. doi:10.1006/bbrc.1997.7113. PMID 9268706.
Krause M, Sechi AS, Konradt M, et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.". J. Cell Biol. 149 (1): 181-94. PMID 10747096.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543-8. doi:10.1073/pnas.160270997. PMID 10931946.
Lambrechts A, Kwiatkowski AV, Lanier LM, et al. (2000). "cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains.". J. Biol. Chem. 275 (46): 36143-51. doi:10.1074/jbc.M006274200. PMID 10945997.
Klostermann A, Lutz B, Gertler F, Behl C (2001). "The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain.". J. Biol. Chem. 275 (50): 39647-53. doi:10.1074/jbc.M006316200. PMID 10993894.
Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.". J. Biol. Chem. 277 (31): 28238-46. doi:10.1074/jbc.M202783200. PMID 12029088.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.". J. Biol. Chem. 278 (49): 49031-43. doi:10.1074/jbc.M308104200. PMID 14506234.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.". Dev. Cell 7 (4): 571-83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.
Lafuente EM, van Puijenbroek AA, Krause M, et al. (2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.". Dev. Cell 7 (4): 585-95. doi:10.1016/j.devcel.2004.07.021. PMID 15469846.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rotter B, Bournier O, Nicolas G, et al. (2005). "AlphaII-spectrin interacts with Tes and EVL, two actin-binding proteins located at cell contacts.". Biochem. J. 388 (Pt 2): 631-8. doi:10.1042/BJ20041502. PMID 15656790.
Barzik M, Kotova TI, Higgs HN, et al. (2005). "Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins.". J. Biol. Chem. 280 (31): 28653-62. doi:10.1074/jbc.M503957200. PMID 15939738.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Bournier O, Kroviarski Y, Rotter B, et al. (2006). "Spectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerization.". Biol. Cell 98 (5): 279-93. doi:10.1042/BC20050024. PMID 16336193.
Bausen M, Fuhrmann JC, Betz H, O'sullivan GA (2006). "The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members.". Mol. Cell. Neurosci. 31 (2): 376-86. doi:10.1016/j.mcn.2005.11.004. PMID 16376568.