Ethylbenzene hydroxylase

From Wikipedia, the free encyclopedia

In enzymology, an ethylbenzene hydroxylase (EC 1.17.99.2) is an enzyme that catalyzes the chemical reaction

ethylbenzene + H₂O + acceptor (S)-1-phenylethanol + reduced acceptor

The 3 substrates of this enzyme are ethylbenzene, H₂O, and acceptor, whereas its two products are (S)-1-phenylethanol and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with other acceptors. The systematic name of this enzyme class is ethylbenzene:acceptor oxidoreductase. Other names in common use include ethylbenzene dehydrogenase, and ethylbenzene:(acceptor) oxidoreductase. This enzyme participates in ethylbenzene degradation.

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2IVF.

[edit] References

• IUBMB entry for 1.17.99.2
• BRENDA references for 1.17.99.2 (Recommended.)
• PubMed references for 1.17.99.2
• PubMed Central references for 1.17.99.2
• Google Scholar references for 1.17.99.2
• Kniemeyer O, Heider J (2001). "Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidizing molybdenum/iron-sulfur/heme enzyme". J. Biol. Chem. 276: 21381–6. doi:10.1074/jbc.M101679200. PMID 11294876. 
• Johnson HA, Pelletier DA, Spormann AM (2001). "Isolation and characterization of anaerobic ethylbenzene dehydrogenase, a novel Mo-Fe-S enzyme". J. Bacteriol. 183: 4536–42. doi:10.1128/JB.183.15.4536-4542.2001. PMID 11443088. 

[edit] External links

• IUBMB entry for 1.17.99.2

• KEGG entry for 1.17.99.2

• BRENDA entry for 1.17.99.2

• NiceZyme view of 1.17.99.2

• EC2PDB: PDB structures for 1.17.99.2

• PRIAM entry for 1.17.99.2

• PUMA2 entry for 1.17.99.2

• IntEnz: Integrated Enzyme entry for 1.17.99.2

• MetaCyc entry for 1.17.99.2

• Atomic-resolution structures of enzymes belonging to this class