Talk:Estrogen receptor
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There's a review in this week's JCI detailing the role of the ER in disease. Possibly useful: Deroo BJ, Korach KS. Estrogen receptors and human disease. J Clin Invest 2006;116:561-70. PMID 16511588. JFW | T@lk 22:58, 9 March 2006 (UTC)
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[edit] Image
I just wanted to point out that the picture labeled "an estrogen receptor dimer" is actually a dimer of the Ligand binding domain of Estrogen Receptor. No one has yet to be able to crystalize the whole protien, because the hinge region is so flexible. The two crystal structures I seen for ER are the Ligand binding domain dimer (shown here) and the DNA binding domain dimer.
[edit] domain structure
"AF1 / Growth Hormone binding"
Can anyone provide a reference that explains the relationship between AF1 and growth hormone?--JWSchmidt 20:11, 13 June 2006 (UTC)
[edit] signal transduction
Are not ERs type I nuclear receptors that exist in cytosol prior to estrogen binding and enter the cell nucleus as a hormone-receptor complex after the hormone is bound? The current page indicates othewise. 129.81.97.247 04:08, 29 March 2007 (UTC)
- I'm not sure, I've never really considered this point, but now you mention it, I've seen evidence for both. For example, in histological stains used to detect ER positive breast cancer, the ER levels in the nucleus are higher than the cytosol (in ER+, ER- and healthy cells). Joe D (t) 19:11, 22 April 2007 (UTC)
- Sure, but first of all you should consider that breast cancer cells may not reflect the normal physiological situation, and furthermore I think the evidence is quite clear for unbound ER to be in the cytoplasm. See for example: Segnitz B & Gehring U. Subunit structure of the nonactivated human estrogen receptor. Proc Natl Acad Sci U S A (1995) 92: pp. 2179-2183 --Nico80 (talk) 05:36, 15 February 2008 (UTC)
[edit] Non genomic effects (?)
I'm not sure if it's really correct to talk about genomic vs non genomic actions of the ER, or of estrogen for that matters. I know that the term is widely used in the literature, but that does not really make it correct... don't you think "rapid" vs. "slow" or "non classical" vs "classical" would be much better options? Rapid effect do at the end impact on gene transcription, so they are in fact "genomic", just in a different way. --Nico80 (talk) 05:41, 15 February 2008 (UTC)
