Erythro-3-hydroxyaspartate ammonia-lyase

From Wikipedia, the free encyclopedia

In enzymology, an erythro-3-hydroxyaspartate ammonia-lyase (EC 4.3.1.20) is an enzyme that catalyzes the chemical reaction

erythro-3-hydroxy-Ls-aspartate oxaloacetate + NH₃

Hence, this enzyme has one substrate, erythro-3-hydroxy-Ls-aspartate, and two products, oxaloacetate and NH₃.

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming). Other names in common use include 3-hydroxyaspartate dehydratase, erythro-beta-hydroxyaspartate dehydratase, erythro-3-hydroxyaspartate dehydratase, erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating), and erythro-3-hydroxy-Ls-aspartate ammonia-lyase. It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 4.3.1.20
• BRENDA references for 4.3.1.20 (Recommended.)
• PubMed references for 4.3.1.20
• PubMed Central references for 4.3.1.20
• Google Scholar references for 4.3.1.20
• Gibbs RG, Morris JG (1965). "Purification and properties of erythro-beta-hydroxyasparate dehydratase from Micrococcus denitrificans". Biochem. J. 97: 547–54. PMID 16749162. 

[edit] External links

• IUBMB entry for 4.3.1.20

• KEGG entry for 4.3.1.20

• BRENDA entry for 4.3.1.20

• NiceZyme view of 4.3.1.20

• EC2PDB: PDB structures for 4.3.1.20

• PRIAM entry for 4.3.1.20

• PUMA2 entry for 4.3.1.20

• IntEnz: Integrated Enzyme entry for 4.3.1.20

• MetaCyc entry for 4.3.1.20

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047447: erythro-3-hydroxyaspartate ammonia-lyase

• AMIGO entry for GO code 0047447: erythro-3-hydroxyaspartate ammonia-lyase