ERN1

From Wikipedia, the free encyclopedia

Endoplasmic reticulum to nucleus signalling 1

PDB rendering based on 2hz6.

Available structures: 2hz6

Identifiers

Symbol(s)

ERN1; FLJ30999; IRE1; IRE1P; MGC163277; MGC163279

External IDs

OMIM: 604033 MGI: 1930134 HomoloGene: 55580

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity • hydrolase activity • endoribonuclease activity, producing 5'-phosphomonoesters
Cellular Component:	• endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral to membrane • integral to endoplasmic reticulum membrane
Biological Process:	• electron transport • transcription • regulation of transcription, DNA-dependent • mRNA processing • apoptosis • induction of apoptosis • unfolded protein response, activation of signaling protein activity • cell cycle arrest • protein amino acid autophosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001433 (mRNA)
NP_001424 (protein)

NM_023913 (mRNA)
NP_076402 (protein)

Location

Chr 17: 59.48 - 59.56 Mb

Chr 11: 106.21 - 106.3 Mb

Pubmed search

[1]

[2]

Endoplasmic reticulum to nucleus signalling 1, also known as ERN1, is a human gene.^[1]

The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ERN1 endoplasmic reticulum to nucleus signalling 1.

[edit] Further reading

Tirasophon W, Welihinda AA, Kaufman RJ (1998). "A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.". Genes Dev. 12 (12): 1812-24. PMID 9637683.
Katayama T, Imaizumi K, Sato N, et al. (2000). "Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.". Nat. Cell Biol. 1 (8): 479-85. doi:10.1038/70265. PMID 10587643.
Urano F, Wang X, Bertolotti A, et al. (2000). "Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.". Science 287 (5453): 664-6. PMID 10650002.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Iwawaki T, Hosoda A, Okuda T, et al. (2001). "Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.". Nat. Cell Biol. 3 (2): 158-64. doi:10.1038/35055065. PMID 11175748.
Yoneda T, Imaizumi K, Oono K, et al. (2001). "Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress.". J. Biol. Chem. 276 (17): 13935-40. doi:10.1074/jbc.M010677200. PMID 11278723.
Lee K, Tirasophon W, Shen X, et al. (2002). "IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.". Genes Dev. 16 (4): 452-66. doi:10.1101/gad.964702. PMID 11850408.
Liu CY, Wong HN, Schauerte JA, Kaufman RJ (2002). "The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain.". J. Biol. Chem. 277 (21): 18346-56. doi:10.1074/jbc.M112454200. PMID 11897784.
Nishitoh H, Matsuzawa A, Tobiume K, et al. (2002). "ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.". Genes Dev. 16 (11): 1345-55. doi:10.1101/gad.992302. PMID 12050113.
Marcu MG, Doyle M, Bertolotti A, et al. (2003). "Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.". Mol. Cell. Biol. 22 (24): 8506-13. PMID 12446770.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Liu CY, Xu Z, Kaufman RJ (2003). "Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha.". J. Biol. Chem. 278 (20): 17680-7. doi:10.1074/jbc.M300418200. PMID 12637535.
Kaneko M, Niinuma Y, Nomura Y (2004). "Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2.". Biol. Pharm. Bull. 26 (7): 931-5. PMID 12843613.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Shang J, Lehrman MA (2004). "Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts.". Biochem. Biophys. Res. Commun. 317 (2): 390-6. doi:10.1016/j.bbrc.2004.03.058. PMID 15063770.
Oono K, Yoneda T, Manabe T, et al. (2004). "JAB1 participates in unfolded protein responses by association and dissociation with IRE1.". Neurochem. Int. 45 (5): 765-72. doi:10.1016/j.neuint.2004.01.003. PMID 15234121.
Huang ZM, Tan T, Yoshida H, et al. (2005). "Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress.". Mol. Cell. Biol. 25 (17): 7522-33. doi:10.1128/MCB.25.17.7522-7533.2005. PMID 16107700.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Hetz C, Bernasconi P, Fisher J, et al. (2006). "Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.". Science 312 (5773): 572-6. doi:10.1126/science.1123480. PMID 16645094.
Oikawa D, Tokuda M, Iwawaki T (2007). "Site-specific cleavage of CD59 mRNA by endoplasmic reticulum-localized ribonuclease, IRE1.". Biochem. Biophys. Res. Commun. 360 (1): 122-7. doi:10.1016/j.bbrc.2007.06.020. PMID 17585877.