EPH receptor B4

From Wikipedia, the free encyclopedia

EPH receptor B4

PDB rendering based on 2bba.

Available structures: 2bba, 2hle

Identifiers

Symbol(s)

EPHB4; HTK; MYK1; TYRO11

External IDs

OMIM: 600011 MGI: 104757 HomoloGene: 20939

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • receptor activity • ephrin receptor activity • receptor binding • ATP binding • axon guidance receptor activity • transferase activity
Cellular Component:	• integral to plasma membrane • cell surface • membrane • integral to membrane
Biological Process:	• protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • axon guidance • learning • cell proliferation • organ morphogenesis • regulation of angiogenesis • regulation of neuronal synaptic plasticity • positive regulation of long-term neuronal synaptic plasticity • regulation of axonogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004444 (mRNA)
NP_004435 (protein)

NM_010144 (mRNA)
NP_034274 (protein)

Location

Chr 7: 100.24 - 100.26 Mb

Chr 5: 137.58 - 137.6 Mb

Pubmed search

[1]

[2]

EPH receptor B4, also known as EPHB4, is a human gene.^[1]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.^[1]

[edit] References

^ ^a ^b Entrez Gene: EPHB4 EPH receptor B4.

[edit] Further reading

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
Andres AC, Reid HH, Zürcher G, et al. (1994). "Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis.". Oncogene 9 (5): 1461–7. PMID 8152808.
Bennett BD, Wang Z, Kuang WJ, et al. (1994). "Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily.". J. Biol. Chem. 269 (19): 14211–8. PMID 8188704.
Berclaz G, Andres AC, Albrecht D, et al. (1996). "Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.". Biochem. Biophys. Res. Commun. 226 (3): 869–75. doi:10.1006/bbrc.1996.1442. PMID 8831703.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403–4. PMID 9267020.
Nikolova Z, Djonov V, Zuercher G, et al. (1998). "Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis.". J. Cell. Sci. 111 ( Pt 18): 2741–51. PMID 9718367.
Tang XX, Brodeur GM, Campling BG, Ikegaki N (1999). "Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma.". Clin. Cancer Res. 5 (2): 455–60. PMID 10037197.
Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). "Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.". Mol. Cell 4 (3): 403–14. PMID 10518221.
Dalva MB, Takasu MA, Lin MZ, et al. (2001). "EphB receptors interact with NMDA receptors and regulate excitatory synapse formation.". Cell 103 (6): 945–56. PMID 11136979.
Wilson MD, Riemer C, Martindale DW, et al. (2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.". Nucleic Acids Res. 29 (6): 1352–65. PMID 11239002.