EPH receptor A2

From Wikipedia, the free encyclopedia

EPH receptor A2

PDB rendering based on 1mqb.

Available structures: 1mqb

Identifiers

Symbol(s)

EPHA2; ECK

External IDs

OMIM: 176946 MGI: 95278 HomoloGene: 20929

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • receptor activity • ephrin receptor activity • ATP binding • transferase activity
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane
Biological Process:	• protein amino acid phosphorylation • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • multicellular organismal development • neuron differentiation • ephrin receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004431 (mRNA)
NP_004422 (protein)

XM_982454 (mRNA)
XP_987548 (protein)

Location

Chr 1: 16.32 - 16.36 Mb

Chr 4: 140.57 - 140.6 Mb

Pubmed search

[1]

[2]

EPH receptor A2, also known as EPHA2, is a human gene.^[1]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.^[2]

[edit] References

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Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
Kinch MS, Carles-Kinch K (2003). "Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer.". Clin. Exp. Metastasis 20 (1): 59–68. PMID 12650608.
Walker-Daniels J, Hess AR, Hendrix MJ, Kinch MS (2003). "Differential regulation of EphA2 in normal and malignant cells.". Am. J. Pathol. 162 (4): 1037–42. PMID 12651595.
Lindberg RA, Hunter T (1991). "cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.". Mol. Cell. Biol. 10 (12): 6316–24. PMID 2174105.
Pandey A, Shao H, Marks RM, et al. (1995). "Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis.". Science 268 (5210): 567–9. PMID 7536959.
Pandey A, Duan H, Dixit VM (1995). "Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase.". J. Biol. Chem. 270 (33): 19201–4. PMID 7543898.
Ruiz JC, Robertson EJ (1994). "The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development.". Mech. Dev. 46 (2): 87–100. PMID 7918100.
Davis S, Gale NW, Aldrich TH, et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.". Science 266 (5186): 816–9. PMID 7973638.
Pandey A, Lazar DF, Saltiel AR, Dixit VM (1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.". J. Biol. Chem. 269 (48): 30154–7. PMID 7982920.
Ganju P, Shigemoto K, Brennan J, et al. (1994). "The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development.". Oncogene 9 (6): 1613–24. PMID 8183555.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9–19. PMID 8755474.
Sulman EP, Tang XX, Allen C, et al. (1997). "ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers.". Genomics 40 (2): 371–4. doi:10.1006/geno.1996.4569. PMID 9119409.
Kozlosky CJ, VandenBos T, Park L, et al. (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.". Cytokine 9 (8): 540–9. doi:10.1006/cyto.1997.0199. PMID 9245480.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403–4. PMID 9267020.