EPHB6

From Wikipedia, the free encyclopedia

EPH receptor B6

Identifiers

EPHB6; HEP; MGC129910; MGC129911

External IDs

OMIM: 602757 MGI: 1096338 HomoloGene: 20940

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • receptor activity • ephrin receptor activity • ATP binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004445 (mRNA)
NP_004436 (protein)

NM_007680 (mRNA)
NP_031706 (protein)

Location

Chr 7: 142.27 - 142.28 Mb

Chr 6: 41.54 - 41.55 Mb

Pubmed search

[1]

[2]

EPH receptor B6, also known as EPHB6, is a human gene.^[1]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.^[1]

[edit] References

^ ^a ^b Entrez Gene: EPHB6 EPH receptor B6.

[edit] Further reading

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309-45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151-81. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033-44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177-244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993-1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155-64. PMID 11256076.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Matsuoka H, Iwata N, Ito M, et al. (1997). "Expression of a kinase-defective Eph-like receptor in the normal human brain.". Biochem. Biophys. Res. Commun. 235 (3): 487-92. doi:10.1006/bbrc.1997.6812. PMID 9207182.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403-4. PMID 9267020.
Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779-84. PMID 9707552.
Munthe E, Rian E, Holien T, et al. (2000). "Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6.". FEBS Lett. 466 (1): 169-74. PMID 10648835.
Shimoyama M, Matsuoka H, Tamekane A, et al. (2000). "T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells.". Growth Factors 18 (1): 63-78. PMID 10831073.
Tang XX, Zhao H, Robinson ME, et al. (2000). "Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma.". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10936-41. doi:10.1073/pnas.190123297. PMID 10984508.
Luo H, Wan X, Wu Y, Wu J (2001). "Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells.". J. Immunol. 167 (3): 1362-70. PMID 11466354.