EPHA6

From Wikipedia, the free encyclopedia

EPH receptor A6

Identifiers

EPHA6; DKFZp434C1418; EPA6; FLJ35246; PRO57066

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • receptor activity • ephrin receptor activity • ATP binding • transferase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway

Orthologs

Human

Mouse

Refseq

XM_001126591 (mRNA)
XP_001126591 (protein)

NM_007938 (mRNA)
NP_031964 (protein)

Location

Chr 3: 98.02 - 98.95 Mb

Chr 16: 59.6 - 60.55 Mb

Pubmed search

[1]

[2]

EPH receptor A6, also known as EPHA6, is a human gene.^[1]

[edit] References

^ Entrez Gene: EPHA6 EPH receptor A6.

[edit] Further reading

Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177-244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993-1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Manning G, Whyte DB, Martinez R, et al. (2003). "The protein kinase complement of the human genome.". Science 298 (5600): 1912-34. doi:10.1126/science.1075762. PMID 12471243.
Nakamoto T, Kain KH, Ginsberg MH (2004). "Neurobiology: New connections between integrins and axon guidance.". Curr. Biol. 14 (3): R121-3. PMID 14986683.
Yamaguchi Y, Pasquale EB (2004). "Eph receptors in the adult brain.". Curr. Opin. Neurobiol. 14 (3): 288-96. doi:10.1016/j.conb.2004.04.003. PMID 15194108.
Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function.". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 10 (4): 304-14. doi:10.1177/1073858403262221. PMID 15271258.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9-19. PMID 8755474.
Aasheim HC, Munthe E, Funderud S, et al. (2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.". Blood 95 (1): 221-30. PMID 10607706.
Prevost N, Woulfe D, Tanaka T, Brass LF (2002). "Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9219-24. doi:10.1073/pnas.142053899. PMID 12084815.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Hafner C, Schmitz G, Meyer S, et al. (2004). "Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers.". Clin. Chem. 50 (3): 490-9. doi:10.1373/clinchem.2003.026849. PMID 14726470.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.