EPB41L2

From Wikipedia, the free encyclopedia

Erythrocyte membrane protein band 4.1-like 2

Identifiers

EPB41L2; 4.1-G; DKFZp781D1972; DKFZp781H1755

External IDs

OMIM: 603237 MGI: 103009 HomoloGene: 37478

Gene ontology
Molecular Function:	• actin binding • structural molecule activity • structural constituent of cytoskeleton • binding
Cellular Component:	• cytoplasm • cytoskeleton • plasma membrane • spectrin • membrane
Biological Process:	• cortical actin cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001431 (mRNA)
NP_001422 (protein)

XM_991404 (mRNA)
XP_996498 (protein)

Location

Chr 6: 131.2 - 131.43 Mb

Chr 10: 25.05 - 25.21 Mb

Pubmed search

[1]

[2]

Erythrocyte membrane protein band 4.1-like 2, also known as EPB41L2, is a human gene.^[1]

[edit] References

^ Entrez Gene: EPB41L2 erythrocyte membrane protein band 4.1-like 2.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Walensky LD, Gascard P, Fields ME, et al. (1998). "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1.". J. Cell Biol. 141 (1): 143–53. PMID 9531554.
Parra M, Gascard P, Walensky LD, et al. (1998). "Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family.". Genomics 49 (2): 298–306. doi:10.1006/geno.1998.5265. PMID 9598318.
Peters LL, Weier HU, Walensky LD, et al. (1999). "Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.". Genomics 54 (2): 348–50. doi:10.1006/geno.1998.5537. PMID 9828140.
Shen L, Liang F, Walensky LD, Huganir RL (2001). "Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association.". J. Neurosci. 20 (21): 7932–40. PMID 11050113.
Kontrogianni-Konstantopoulos A, Frye CS, Benz EJ, Huang SC (2001). "The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation.". J. Biol. Chem. 276 (23): 20679–87. doi:10.1074/jbc.M010581200. PMID 11274145.
Gimm JA, An X, Nunomura W, Mohandas N (2002). "Functional characterization of spectrin-actin-binding domains in 4.1 family of proteins.". Biochemistry 41 (23): 7275–82. PMID 12044158.
Binda AV, Kabbani N, Lin R, Levenson R (2002). "D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N.". Mol. Pharmacol. 62 (3): 507–13. PMID 12181426.
Delhommeau F, Vasseur-Godbillon C, Leclerc P, et al. (2002). "A splicing alteration of 4.1R pre-mRNA generates 2 protein isoforms with distinct assembly to spindle poles in mitotic cells.". Blood 100 (7): 2629–36. doi:10.1182/blood.V100.7.2629. PMID 12239178.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lu D, Yan H, Othman T, et al. (2004). "Cytoskeletal protein 4.1G binds to the third intracellular loop of the A1 adenosine receptor and inhibits receptor action.". Biochem. J. 377 (Pt 1): 51–9. doi:10.1042/BJ20030952. PMID 12974671.
Ralston KJ, Hird SL, Zhang X, et al. (2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large.". J. Biol. Chem. 279 (32): 33816–28. doi:10.1074/jbc.M401040200. PMID 15138281.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.