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| Enterovirus cis-acting replication element |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Bateman A |
| Avg length: |
61.0 nucleotides |
| Avg identity: |
81% |
|
Enterovirus cis-acting replication element is a small RNA hairpin in the coding region of protein 2C as the site in PV1(M) RNA that is used as the primary template for the in vitro uridylylation [1-2]. The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of Uridine monophosphate (UMP) to the terminal protein VPg, yielding VPgpU and VPgpUpU.
[edit] References
- [1] Paul, AV; Rieder E, Kim DW, van Boom JH, Wimmer E (2000). "Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg". J Virol 74: 10359–10370. doi:10.1128/JVI.74.22.10359-10370.2000. PMID 11044080.
- [2] Goodfellow, I; Chaudhry Y, Richardson A, Meredith J, Almond JW, Barclay W, Evans DJ (2000). "Identification of a cis-acting replication element within the poliovirus coding region". J Virol 74: 4590–4600. doi:10.1128/JVI.74.10.4590-4600.2000. PMID 10775595.
[edit] External links
