Enterostatin

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Enterostatin is a pentapeptide produced from exocrine pancreas and gastrointestinal tract that selectively reduces fat intake. Its effects include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion. At the end level, it initiates a sensation of fullness of stomach which could be the reason for its role in regulation of fat intake and reduction of body weight.