Ent-copalyl diphosphate synthase

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In enzymology, an ent-copalyl diphosphate synthase (EC 5.5.1.13) is an enzyme that catalyzes the chemical reaction

geranylgeranyl diphosphate $\rightleftharpoons$ ent-copalyl diphosphate

Hence, this enzyme has one substrate, geranylgeranyl diphosphate, and one product, ent-copalyl diphosphate.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is ent-copalyl-diphosphate lyase (decyclizing). Other names in common use include ent-kaurene synthase A, and ent-kaurene synthetase A. This enzyme participates in diterpenoid biosynthesis.

[edit] References

IUBMB entry for 5.5.1.13
BRENDA references for 5.5.1.13 (Recommended.)
PubMed references for 5.5.1.13
PubMed Central references for 5.5.1.13
Google Scholar references for 5.5.1.13
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Kawaide H, Imai R, Sassa T, Kamiya Y (1997). "Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis". J. Biol. Chem. 272: 21706–12. doi:10.1074/jbc.272.35.21706. PMID 9268298.
W, Sassa T (2000). "Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase". Biosci. Biotechnol. Biochem. 64: 660–4. doi:10.1271/bbb.64.660. PMID 10803977.