ENTPD5

From Wikipedia, the free encyclopedia

Ectonucleoside triphosphate diphosphohydrolase 5

Identifiers

ENTPD5; CD39L4; MGC163357; MGC163359; NTPDase-5; PCPH

External IDs

OMIM: 603162 MGI: 1321385 HomoloGene: 37457

Gene ontology
Molecular Function:	• magnesium ion binding • calcium ion binding • hydrolase activity • nucleoside-diphosphatase activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001249 (mRNA)
NP_001240 (protein)

NM_001026214 (mRNA)
NP_001021385 (protein)

Location

Chr 14: 73.5 - 73.55 Mb

Chr 12: 85.26 - 85.3 Mb

Pubmed search

[1]

[2]

Ectonucleoside triphosphate diphosphohydrolase 5, also known as ENTPD5, is a human gene.^[1]

ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.^[1]

[edit] References

^ ^a ^b Entrez Gene: ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5.

[edit] Further reading

Chadwick BP, Frischauf AM (1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes.". Mamm. Genome 8 (9): 668–72. PMID 9271669.
Chadwick BP, Frischauf AM (1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.". Genomics 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
Mulero JJ, Yeung G, Nelken ST, Ford JE (1999). "CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates.". J. Biol. Chem. 274 (29): 20064–7. PMID 10400613.
Recio JA, Zambrano N, Peña L, et al. (2000). "The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells.". Mol. Carcinog. 27 (3): 229–36. PMID 10708485.
Mulero JJ, Yeung G, Nelken ST, et al. (2000). "Biochemical characterization of CD39L4.". Biochemistry 39 (42): 12924–8. PMID 11041857.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Blánquez MJ, Regadera J, Mariño J, et al. (2003). "Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia.". Mol. Carcinog. 35 (4): 186–95. doi:10.1002/mc.10091. PMID 12489110.
Murphy-Piedmonte DM, Crawford PA, Kirley TL (2005). "Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase.". Biochim. Biophys. Acta 1747 (2): 251–9. doi:10.1016/j.bbapap.2004.11.017. PMID 15698960.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
Regadera J, Blánquez MJ, González-Peramato P, et al. (2006). "PCPH expression is an early event in the development of testicular germ cell tumors.". Int. J. Oncol. 28 (3): 595–604. PMID 16465363.
Villar J, Arenas MI, MacCarthy CM, et al. (2007). "PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism.". Cancer Res. 67 (22): 10859–68. doi:10.1158/0008-5472.CAN-07-2041. PMID 18006831.