ENPP7

From Wikipedia, the free encyclopedia

Ectonucleotide pyrophosphatase/phosphodiesterase 7

Identifiers

ENPP7; ALK-SMase; MGC50179

External IDs

Gene ontology
Molecular Function:	• sphingomyelin phosphodiesterase activity • hydrolase activity
Cellular Component:	• Golgi apparatus • microvillus • membrane • integral to membrane
Biological Process:	• sphingomyelin metabolic process • metabolic process • negative regulation of DNA replication • negative regulation of cell proliferation • nucleotide metabolic process

Orthologs

Human

Mouse

n/a

Refseq

NM_178543 (mRNA)
NP_848638 (protein)

XM_993737 (mRNA)
XP_998831 (protein)

Location

Chr 17: 75.32 - 75.33 Mb

Chr 11: 118.8 - 118.81 Mb

Pubmed search

[1]

[2]

Ectonucleotide pyrophosphatase/phosphodiesterase 7, also known as ENPP7, is a human gene.^[1]

[edit] References

^ Entrez Gene: ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7.

[edit] Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Duan RD, Cheng Y, Hansen G, et al. (2004). "Purification, localization, and expression of human intestinal alkaline sphingomyelinase.". J. Lipid Res. 44 (6): 1241–50. doi:10.1194/jlr.M300037-JLR200. PMID 12671034.
Duan RD, Bergman T, Xu N, et al. (2003). "Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.". J. Biol. Chem. 278 (40): 38528–36. doi:10.1074/jbc.M305437200. PMID 12885774.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wu J, Cheng Y, Nilsson A, Duan RD (2004). "Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells.". Carcinogenesis 25 (8): 1327–33. doi:10.1093/carcin/bgh140. PMID 15016655.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Wu J, Hansen GH, Nilsson A, Duan RD (2005). "Functional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesis.". Biochem. J. 386 (Pt 1): 153–60. doi:10.1042/BJ20041455. PMID 15458386.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wu J, Cheng Y, Palmberg C, et al. (2005). "Cloning of alkaline sphingomyelinase from rat intestinal mucosa and adjusting of the hypothetical protein XP_221184 in GenBank.". Biochim. Biophys. Acta 1687 (1-3): 94–102. doi:10.1016/j.bbalip.2004.11.006. PMID 15708357.
Wu J, Nilsson A, Jönsson BA, et al. (2006). "Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity.". Biochem. J. 394 (Pt 1): 299–308. doi:10.1042/BJ20051121. PMID 16255717.