ELAVL3

From Wikipedia, the free encyclopedia

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

PDB rendering based on 1d8z.

Available structures: 1d8z, 1d9a, 1fnx, 1fxl, 1g2e

Identifiers

Symbol(s)

ELAVL3; DKFZp547J036; HUC; HUCL; MGC20653; PLE21

External IDs

OMIM: 603458 MGI: 109157 HomoloGene: 31035

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • mRNA 3'-UTR binding
Biological Process:	• multicellular organismal development • nervous system development • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001420 (mRNA)
NP_001411 (protein)

NM_010487 (mRNA)
NP_034617 (protein)

Location

Chr 19: 11.42 - 11.45 Mb

Chr 9: 21.77 - 21.79 Mb

Pubmed search

[1]

[2]

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C), also known as ELAVL3, is a human gene.^[1]

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C).

[edit] Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library.". Int. J. Cancer 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604.
Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.". Mol. Cell. Biol. 20 (13): 4765–72. PMID 10848602.
Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA.". Biochem. Biophys. Res. Commun. 256 (2): 263–8. doi:10.1006/bbrc.1999.0282. PMID 10079173.
Van Tine BA, Knops JF, Butler A, et al. (1998). "Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique.". Genomics 53 (3): 296–9. doi:10.1006/geno.1998.5468. PMID 9799595.
Sakai K, Gofuku M, Kitagawa Y, et al. (1994). "A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma.". Biochem. Biophys. Res. Commun. 199 (3): 1200–8. doi:10.1006/bbrc.1994.1358. PMID 7511893.