ELAVL1

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ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
Identifiers
Symbol(s) ELAVL1; ELAV1; HUR; Hua; MelG
External IDs OMIM: 603466 MGI: 1100851 HomoloGene: 20367
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1994 15568
Ensembl ENSG00000066044 ENSMUSG00000040028
Uniprot Q15717 Q3TT05
Refseq NM_001419 (mRNA)
NP_001410 (protein)		 NM_010485 (mRNA)
NP_034615 (protein)
Location Chr 19: 7.93 - 8.42 Mb Chr 8: 4.29 - 4.33 Mb
Pubmed search [1] [2]

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R), also known as ELAVL1, is a human gene.

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It stabilizes mRNAs and thereby regulates gene expression.[1]

[edit] References

  1. ^ Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R).

[edit] Further reading

  • Nabors LB, Suswam E, Huang Y, Yang X, Johnson MJ, King PH (2003). "Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR.". Cancer Res. 63 (14): 4181-87. PMID 12874024. 
  • Abdelmohsen K, Lal A, Kim HH, Gorospe M (2007). "Posttranscriptional orchestration of an anti-apoptotic program by HuR.". Cell Cycle 6 (11): 1288-92. PMID 17534146. 
  • Ma WJ, Cheng S, Campbell C, et al. (1996). "Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein.". J. Biol. Chem. 271 (14): 8144-51. PMID 8626503. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Ma WJ, Furneaux H (1997). "Localization of the human HuR gene to chromosome 19p13.2.". Hum. Genet. 99 (1): 32-3. PMID 9003489. 
  • Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA.". Biochem. Biophys. Res. Commun. 256 (2): 263-8. doi:10.1006/bbrc.1999.0282. PMID 10079173. 
  • Wang W, Furneaux H, Cheng H, et al. (2000). "HuR regulates p21 mRNA stabilization by UV light.". Mol. Cell. Biol. 20 (3): 760-9. PMID 10629032. 
  • Blaxall BC, Pellett AC, Wu SC, et al. (2000). "Purification and characterization of beta-adrenergic receptor mRNA-binding proteins.". J. Biol. Chem. 275 (6): 4290-7. PMID 10660597. 
  • Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.". Mol. Cell. Biol. 20 (13): 4765-72. PMID 10848602. 
  • Spångberg K, Wiklund L, Schwartz S (2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities.". Virology 274 (2): 378-90. doi:10.1006/viro.2000.0461. PMID 10964780. 
  • Brennan CM, Gallouzi IE, Steitz JA (2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo.". J. Cell Biol. 151 (1): 1-14. PMID 11018049. 
  • Gallouzi IE, Brennan CM, Steitz JA (2001). "Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock.". RNA 7 (9): 1348-61. PMID 11565755. 
  • Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides.". Science 294 (5548): 1895-901. doi:10.1126/science.1064693. PMID 11729309. 
  • Goldberg-Cohen I, Furneauxb H, Levy AP (2002). "A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR.". J. Biol. Chem. 277 (16): 13635-40. doi:10.1074/jbc.M108703200. PMID 11834731. 
  • Wang W, Fan J, Yang X, et al. (2002). "AMP-activated kinase regulates cytoplasmic HuR.". Mol. Cell. Biol. 22 (10): 3425-36. PMID 11971974. 
  • Yeap BB, Voon DC, Vivian JP, et al. (2002). "Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA.". J. Biol. Chem. 277 (30): 27183-92. doi:10.1074/jbc.M202883200. PMID 12011088. 
  • Li H, Park S, Kilburn B, et al. (2003). "Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase.". J. Biol. Chem. 277 (47): 44623-30. doi:10.1074/jbc.M206187200. PMID 12237300. 
  • Chen CY, Xu N, Shyu AB (2002). "Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization.". Mol. Cell. Biol. 22 (20): 7268-78. PMID 12242302. 
  • Giles KM, Daly JM, Beveridge DJ, et al. (2003). "The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein.". J. Biol. Chem. 278 (5): 2937-46. doi:10.1074/jbc.M208439200. PMID 12431987. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wang W, Yang X, López de Silanes I, et al. (2003). "Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function.". J. Biol. Chem. 278 (29): 27016-23. doi:10.1074/jbc.M300318200. PMID 12730239. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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