ELA3B

From Wikipedia, the free encyclopedia

Elastase 3B, pancreatic

Identifiers

External IDs

MGI: 1915118 HomoloGene: 40574

Gene ontology
Molecular Function:	• pancreatic elastase I activity • peptidase activity
Cellular Component:	• extracellular region
Biological Process:	• proteolysis • cholesterol metabolic process

Orthologs

Human

Mouse

Entrez

23436

67868

Refseq

NM_007352 (mRNA)
NP_031378 (protein)

XM_989961 (mRNA)
XP_995055 (protein)

Pubmed search

[1]

[2]

Elastase 3B, pancreatic, also known as ELA3B, is a human gene.^[1]

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1.^[1]

[edit] References

^ ^a ^b Entrez Gene: ELA3B elastase 3B, pancreatic.

[edit] Further reading

Shirasu Y, Takemura K, Yoshida H, et al. (1988). "Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes.". J. Biochem. 104 (2): 259-64. PMID 2460440.
Avilés FX, Pascual R, Salva M, et al. (1989). "Generation of a subunit III-like protein by autolysis of human and porcine proproteinase e in a binary complex with procarboxypeptidase A.". Biochem. Biophys. Res. Commun. 163 (3): 1191-6. PMID 2675835.
Wendorf P, Geyer R, Sziegoleit A, Linder D (1989). "Localization and characterization of the glycosylation site of human pancreatic elastase 1.". FEBS Lett. 249 (2): 275-8. PMID 2737288.
Moulard M, Kerfelec B, Mallet B, Chapus C (1989). "Identification of a procarboxypeptidase A-truncated protease E binary complex in human pancreatic juice.". FEBS Lett. 250 (2): 166-70. PMID 2753124.
Tani T, Ohsumi J, Mita K, Takiguchi Y (1988). "Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.". J. Biol. Chem. 263 (3): 1231-9. PMID 2826474.
Guy-Crotte O, Barthe C, Basso D, et al. (1988). "Characterization of two glycoproteins of human pancreatic juice: P35, a truncated protease E and P19, precursor of protein X.". Biochem. Biophys. Res. Commun. 156 (1): 318-22. PMID 3178837.
Shen WF, Fletcher TS, Largman C (1987). "Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA.". Biochemistry 26 (12): 3447-52. PMID 3477287.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.