ELA3A

From Wikipedia, the free encyclopedia

Elastase 3A, pancreatic

Identifiers

External IDs

Gene ontology
Molecular Function:	• serine-type endopeptidase activity • pancreatic elastase activity • peptidase activity
Biological Process:	• proteolysis • digestion • cholesterol metabolic process

Orthologs

Human

Mouse

Entrez

10136

n/a

Refseq

NM_005747 (mRNA)
NP_005738 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Elastase 3A, pancreatic, also known as ELA3A, is a human gene.^[1]

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1.^[1]

[edit] References

^ ^a ^b Entrez Gene: ELA3A elastase 3A, pancreatic.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Shimada S, Yamaguchi K, Takahashi M, Ogawa M (2002). "Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells.". Int. J. Mol. Med. 10 (5): 599-603. PMID 12373299.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Tani T, Ohsumi J, Mita K, Takiguchi Y (1988). "Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.". J. Biol. Chem. 263 (3): 1231-9. PMID 2826474.
Shirasu Y, Takemura K, Yoshida H, et al. (1988). "Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes.". J. Biochem. 104 (2): 259-64. PMID 2460440.