EIF5A

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Eukaryotic translation initiation factor 5A
Identifiers
Symbol(s) EIF5A; EIF-5A; EIF5A1; MGC104255; MGC99547; uORF; uORF A
External IDs OMIM: 600187 MGI: 106248 HomoloGene: 1490
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1984 276770
Ensembl ENSG00000132507 n/a
Uniprot P63241 n/a
Refseq NM_001970 (mRNA)
NP_001961 (protein)		 NM_181582 (mRNA)
NP_853613 (protein)
Location Chr 17: 7.15 - 7.16 Mb n/a
Pubmed search [1] [2]

Eukaryotic translation initiation factor 5A, also known as EIF5A, is a human gene.


[edit] Further reading

  • Bevec D, Hauber J (1997). "Eukaryotic initiation factor 5A activity and HIV-1 Rev function.". Biol. Signals 6 (3): 124–33. PMID 9285095. 
  • Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.". Cell Res. 15 (11-12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571. 
  • Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. PMID 1286667. 
  • Chung SI, Park MH, Folk JE, Lewis MS (1991). "Eukaryotic initiation factor 5A: the molecular form of the hypusine-containing protein from human erythrocytes.". Biochim. Biophys. Acta 1076 (3): 448–51. PMID 1900436. 
  • Smit-McBride Z, Dever TE, Hershey JW, Merrick WC (1989). "Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein.". J. Biol. Chem. 264 (3): 1578–83. PMID 2492279. 
  • Park MH, Liu TY, Neece SH, Swiggard WJ (1986). "Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue.". J. Biol. Chem. 261 (31): 14515–9. PMID 3095320. 
  • Koettnitz K, Kappel B, Baumruker T, et al. (1994). "The genomic structure encoding human initiation factor eIF-5A.". Gene 144 (2): 249–52. PMID 7545941. 
  • Klier H, Csonga R, Joäo HC, et al. (1995). "Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from HeLa cells.". Biochemistry 34 (45): 14693–702. PMID 7578077. 
  • Koettnitz K, Wöhl T, Kappel B, et al. (1995). "Identification of a new member of the human eIF-5A gene family.". Gene 159 (2): 283–4. PMID 7622067. 
  • Steinkasserer A, Jones T, Sheer D, et al. (1995). "The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2.". Genomics 25 (3): 749–52. PMID 7759117. 
  • Joe YA, Park MH (1994). "Structural features of the eIF-5A precursor required for posttranslational synthesis of deoxyhypusine.". J. Biol. Chem. 269 (41): 25916–21. PMID 7929297. 
  • Bevec D, Klier H, Holter W, et al. (1994). "Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 10829–33. PMID 7971969. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Ruhl M, Himmelspach M, Bahr GM, et al. (1994). "Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.". J. Cell Biol. 123 (6 Pt 1): 1309–20. PMID 8253832. 
  • Liu YP, Nemeroff M, Yan YP, Chen KY (1997). "Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification.". Biol. Signals 6 (3): 166–74. PMID 9285100. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Singh US, Li Q, Cerione R (1998). "Identification of the eukaryotic initiation factor 5A as a retinoic acid-stimulated cellular binding partner for tissue transglutaminase II.". J. Biol. Chem. 273 (4): 1946–50. PMID 9442029. 
  • Schatz O, Oft M, Dascher C, et al. (1998). "Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5.". Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1607–12. PMID 9465063. 
  • Lee YB, Joe YA, Wolff EC, et al. (1999). "Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor.". Biochem. J. 340 ( Pt 1): 273–81. PMID 10229683. 
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