EIF4G3

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 4 gamma, 3

PDB rendering based on 1hu3.

Available structures: 1hu3

Identifiers

Symbol(s)

EIF4G3; eIF4GII

External IDs

OMIM: 603929 MGI: 1923935 HomoloGene: 2789

Gene ontology
Molecular Function:	• RNA cap binding • RNA binding • translation initiation factor activity • protein binding
Cellular Component:	• eukaryotic translation initiation factor 4F complex
Biological Process:	• regulation of translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003760 (mRNA)
NP_003751 (protein)

XM_924437 (mRNA)
XP_929530 (protein)

Location

Chr 1: 21.01 - 21.38 Mb

Chr 4: 137.27 - 137.48 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 4 gamma, 3, also known as EIF4G3, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3.

[edit] Further reading

Gingras AC, Raught B, Sonenberg N (2000). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.". Annu. Rev. Biochem. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Gradi A, Imataka H, Svitkin YV, et al. (1998). "A novel functional human eukaryotic translation initiation factor 4G.". Mol. Cell. Biol. 18 (1): 334–42. PMID 9418880.
Imataka H, Gradi A, Sonenberg N (1999). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMID 9857202.
Pyronnet S, Imataka H, Gingras AC, et al. (1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.". EMBO J. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMID 9878069.
Waskiewicz AJ, Johnson JC, Penn B, et al. (1999). "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.". Mol. Cell. Biol. 19 (3): 1871–80. PMID 10022874.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Marcotrigiano J, Lomakin IB, Sonenberg N, et al. (2001). "A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery.". Mol. Cell 7 (1): 193–203. PMID 11172724.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gradi A, Svitkin YV, Sommergruber W, et al. (2003). "Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.". J. Virol. 77 (8): 5026–9. PMID 12663812.
Miura T, Shiratori Y, Shimma N (2004). "Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII.". J. Biomol. NMR 27 (3): 279–80. PMID 12975586.
Qin H, Raught B, Sonenberg N, et al. (2004). "Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I.". J. Biol. Chem. 278 (49): 48570–9. doi:10.1074/jbc.M308781200. PMID 14507913.
Gradi A, Foeger N, Strong R, et al. (2004). "Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro.". J. Virol. 78 (7): 3271–8. PMID 15016848.
Lejeune F, Ranganathan AC, Maquat LE (2004). "eIF4G is required for the pioneer round of translation in mammalian cells.". Nat. Struct. Mol. Biol. 11 (10): 992–1000. doi:10.1038/nsmb824. PMID 15361857.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.