EIF4A2

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 4A, isoform 2

Identifiers

EIF4A2; EIF4A; BM-010; DDX2B; EIF4F

External IDs

OMIM: 601102 MGI: 106906 HomoloGene: 1487

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA binding • translation initiation factor activity • protein binding • ATP binding • ATP-dependent helicase activity • hydrolase activity
Cellular Component:	• eukaryotic translation initiation factor 4F complex
Biological Process:	• translation • regulation of translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001967 (mRNA)
NP_001958 (protein)

NM_013506 (mRNA)
NP_038534 (protein)

Location

Chr 3: 187.98 - 187.99 Mb

Chr 16: 23.02 - 23.03 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 4A, isoform 2, also known as EIF4A2, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF4A2 eukaryotic translation initiation factor 4A, isoform 2.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Sudo K, Takahashi E, Nakamura Y (1996). "Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2.". Cytogenet. Cell Genet. 71 (4): 385-8. PMID 8521730.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Li W, Belsham GJ, Proud CG (2001). "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.". J. Biol. Chem. 276 (31): 29111-5. doi:10.1074/jbc.C100284200. PMID 11408474.
Kyono K, Miyashiro M, Taguchi I (2002). "Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro.". Biochem. Biophys. Res. Commun. 292 (3): 659-66. doi:10.1006/bbrc.2002.6702. PMID 11922617.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Sarkar M, Das S, Bandyopadhaya A, et al. (2005). "Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis.". FEBS Lett. 579 (16): 3449-60. doi:10.1016/j.febslet.2005.05.012. PMID 15946665.
Feng P, Everly DN, Read GS (2005). "mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.". J. Virol. 79 (15): 9651-64. doi:10.1128/JVI.79.15.9651-9664.2005. PMID 16014927.
Cheyssac C, Dina C, Leprêtre F, et al. (2006). "EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families.". Diabetes 55 (4): 1171-6. PMID 16567544.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.