EIF4A1

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 4A, isoform 1

PDB rendering based on 2g9n.

Available structures: 2g9n

Identifiers

Symbol(s)

EIF4A1; DDX2A; EIF-4A; EIF4A

External IDs

OMIM: 602641 MGI: 95303 HomoloGene: 68182

Gene ontology
Molecular Function:	• nucleotide binding • RNA cap binding • nucleic acid binding • mRNA binding • translation initiation factor activity • protein binding • ATP binding • ATP-dependent helicase activity • hydrolase activity
Cellular Component:	• eukaryotic translation initiation factor 4F complex
Biological Process:	• translation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001416 (mRNA)
NP_001407 (protein)

NM_144958 (mRNA)
NP_659207 (protein)

Location

Chr 17: 7.42 - 7.42 Mb

Chr 11: 69.48 - 69.49 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 4A, isoform 1, also known as EIF4A1, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF4A1 eukaryotic translation initiation factor 4A, isoform 1.

[edit] Further reading

Reddy NS, Roth WW, Bragg PW, Wahba AJ (1989). "Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells.". Gene 70 (2): 231-43. PMID 3215517.
Kim NS, Kato T, Abe N, Kato S (1993). "Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI.". Nucleic Acids Res. 21 (8): 2012. PMID 8493113.
Kukimoto I, Watanabe S, Taniguchi K, et al. (1997). "Characterization of the cloned promoter of the human initiation factor 4AI gene.". Biochem. Biophys. Res. Commun. 233 (3): 844-7. doi:10.1006/bbrc.1997.6555. PMID 9168945.
Imataka H, Sonenberg N (1997). "Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A.". Mol. Cell. Biol. 17 (12): 6940-7. PMID 9372926.
Gradi A, Imataka H, Svitkin YV, et al. (1998). "A novel functional human eukaryotic translation initiation factor 4G.". Mol. Cell. Biol. 18 (1): 334-42. PMID 9418880.
Craig AW, Haghighat A, Yu AT, Sonenberg N (1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.". Nature 392 (6675): 520-3. doi:10.1038/33198. PMID 9548260.
Jones E, Quinn CM, See CG, et al. (1998). "The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13.". Genomics 53 (2): 248-50. doi:10.1006/geno.1998.5515. PMID 9790779.
Henis-Korenblit S, Strumpf NL, Goldstaub D, Kimchi A (2000). "A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation.". Mol. Cell. Biol. 20 (2): 496-506. PMID 10611228.
Quinn CM, Wiles AP, El-Shanawany T, et al. (2000). "The human eukaryotic initiation factor 4AI gene (EIF4A1) contains multiple regulatory elements that direct high-level reporter gene expression in mammalian cell lines.". Genomics 62 (3): 468-76. doi:10.1006/geno.1999.6031. PMID 10644445.
Cuesta R, Xi Q, Schneider RJ (2000). "Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F.". EMBO J. 19 (13): 3465-74. doi:10.1093/emboj/19.13.3465. PMID 10880459.
Mendell JT, Medghalchi SM, Lake RG, et al. (2000). "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.". Mol. Cell. Biol. 20 (23): 8944-57. PMID 11073994.
Li W, Belsham GJ, Proud CG (2001). "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.". J. Biol. Chem. 276 (31): 29111-5. doi:10.1074/jbc.C100284200. PMID 11408474.
Du MX, Johnson RB, Sun XL, et al. (2002). "Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase.". Biochem. J. 363 (Pt 1): 147-55. PMID 11903057.
Bohnsack MT, Regener K, Schwappach B, et al. (2003). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.". EMBO J. 21 (22): 6205-15. PMID 12426392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yang HS, Cho MH, Zakowicz H, et al. (2004). "A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A.". Mol. Cell. Biol. 24 (9): 3894-906. PMID 15082783.
Mingot JM, Bohnsack MT, Jäkle U, Görlich D (2005). "Exportin 7 defines a novel general nuclear export pathway.". EMBO J. 23 (16): 3227-36. doi:10.1038/sj.emboj.7600338. PMID 15282546.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hinton TM, Coldwell MJ, Carpenter GA, et al. (2007). "Functional analysis of individual binding activities of the scaffold protein eIF4G.". J. Biol. Chem. 282 (3): 1695-708. doi:10.1074/jbc.M602780200. PMID 17130132.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.