EIF2S3

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa

Identifiers

EIF2S3; EIF2; EIF2G; EIF2gamma

External IDs

OMIM: 300161 MGI: 1349431 HomoloGene: 37475

Gene ontology
Molecular Function:	• nucleotide binding • translation initiation factor activity • GTPase activity • GTP binding
Cellular Component:	• cytosolic small ribosomal subunit (sensu Eukaryota) • eukaryotic translation initiation factor 2 complex
Biological Process:	• translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001415 (mRNA)
NP_001406 (protein)

XM_980187 (mRNA)
XP_985281 (protein)

Location

Chr X: 23.98 - 24.01 Mb

Chr X: 90.44 - 90.47 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa, also known as EIF2S3, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa.

[edit] Further reading

Ray MK, Chakraborty A, Datta B, et al. (1993). "Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide.". Biochemistry 32 (19): 5151-9. PMID 8098621.
Gaspar NJ, Kinzy TG, Scherer BJ, et al. (1994). "Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit.". J. Biol. Chem. 269 (5): 3415-22. PMID 8106381.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Brand SR, Kobayashi R, Mathews MB (1997). "The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR.". J. Biol. Chem. 272 (13): 8388-95. PMID 9079663.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Ehrmann IE, Ellis PS, Mazeyrat S, et al. (1998). "Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution.". Hum. Mol. Genet. 7 (11): 1725-37. PMID 9736774.
Cai R, Carpick B, Chun RF, et al. (2000). "HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms.". Arch. Biochem. Biophys. 373 (2): 361-7. doi:10.1006/abbi.1999.1583. PMID 10620360.
Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R (2000). "Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2.". Nucleic Acids Res. 28 (4): 1011-8. PMID 10648795.
Kruger M, Beger C, Li QX, et al. (2000). "Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach.". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8566-71. PMID 10900014.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Filippova GN, Cheng MK, Moore JM, et al. (2005). "Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.". Dev. Cell 8 (1): 31-42. PMID 15669143.
Marques AC, Dupanloup I, Vinckenbosch N, et al. (2006). "Emergence of young human genes after a burst of retroposition in primates.". PLoS Biol. 3 (11): e357. doi:10.1371/journal.pbio.0030357. PMID 16201836.
Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV (2006). "Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases.". Biochem. Biophys. Res. Commun. 338 (4): 1766-72. doi:10.1016/j.bbrc.2005.10.150. PMID 16288713.
Mikami S, Masutani M, Sonenberg N, et al. (2006). "An efficient mammalian cell-free translation system supplemented with translation factors.". Protein Expr. Purif. 46 (2): 348-57. doi:10.1016/j.pep.2005.09.021. PMID 16289705.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.". Mol. Cell Proteomics 6 (4): 575-88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.