EIF2C1

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 2C, 1

PDB rendering based on 1si2.

Available structures: 1si2, 1si3

Identifiers

Symbol(s)

EIF2C1; AGO1; DKFZp686M13167; EIF2C; GERP95; Q99

External IDs

OMIM: 606228 MGI: 2446630 HomoloGene: 81826

Gene ontology
Molecular Function:	• translation initiation factor activity • protein binding
Cellular Component:	• eukaryotic translation initiation factor 2 complex
Biological Process:	• translation • regulation of translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_012199 (mRNA)
NP_036331 (protein)

XM_994455 (mRNA)
XP_999549 (protein)

Location

Chr 1: 36.11 - 36.16 Mb

n/a

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 2C, 1, also known as EIF2C1, is a human gene.^[1]

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.^[1]

[edit] References

^ ^a ^b Entrez Gene: EIF2C1 eukaryotic translation initiation factor 2C, 1.

[edit] Further reading

Carmell MA, Xuan Z, Zhang MQ, Hannon GJ (2002). "The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.". Genes Dev. 16 (21): 2733–42. doi:10.1101/gad.1026102. PMID 12414724.
Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method.". Genomics 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
Cikaluk DE, Tahbaz N, Hendricks LC, et al. (1999). "GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation.". Mol. Biol. Cell 10 (10): 3357–72. PMID 10512872.
Koesters R, Adams V, Betts D, et al. (1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.". Genomics 61 (2): 210–8. doi:10.1006/geno.1999.5951. PMID 10534406.
Martinez J, Patkaniowska A, Urlaub H, et al. (2003). "Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.". Cell 110 (5): 563–74. PMID 12230974.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Doi N, Zenno S, Ueda R, et al. (2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.". Curr. Biol. 13 (1): 41–6. PMID 12526743.
Sasaki T, Shiohama A, Minoshima S, Shimizu N (2004). "Identification of eight members of the Argonaute family in the human genome small star, filled.". Genomics 82 (3): 323–30. PMID 12906857.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ma JB, Ye K, Patel DJ (2004). "Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.". Nature 429 (6989): 318–22. doi:10.1038/nature02519. PMID 15152257.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sen GL, Blau HM (2005). "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies.". Nat. Cell Biol. 7 (6): 633–6. doi:10.1038/ncb1265. PMID 15908945.
Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies.". Nat. Cell Biol. 7 (7): 719–23. doi:10.1038/ncb1274. PMID 15937477.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Chu CY, Rana TM (2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.". PLoS Biol. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMID 16756390.
Kim DH, Villeneuve LM, Morris KV, Rossi JJ (2006). "Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells.". Nat. Struct. Mol. Biol. 13 (9): 793–7. doi:10.1038/nsmb1142. PMID 16936726.
Janowski BA, Huffman KE, Schwartz JC, et al. (2006). "Involvement of AGO1 and AGO2 in mammalian transcriptional silencing.". Nat. Struct. Mol. Biol. 13 (9): 787–92. doi:10.1038/nsmb1140. PMID 16936728.
Sasaki T, Shimizu N (2007). "Evolutionary conservation of a unique amino acid sequence in human DICER protein essential for binding to Argonaute family proteins.". Gene 396 (2): 312–20. doi:10.1016/j.gene.2007.04.001. PMID 17482383.