EIF1AY

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 1A, Y-linked

PDB rendering based on 1d7q.

Available structures: 1d7q

Identifiers

Symbol(s)

EIF1AY;

External IDs

OMIM: 400014 MGI: 95298 HomoloGene: 81626

Gene ontology
Molecular Function:	• RNA binding • translation initiation factor activity • protein binding
Biological Process:	• translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_004681 (mRNA)
NP_004672 (protein)

NM_010120 (mRNA)
NP_034250 (protein)

Location

Chr Y: 21.15 - 21.16 Mb

n/a

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 1A, Y-linked, also known as EIF1AY, is a human gene.^[1]

This gene encodes a protein similar to eukaryotic translation initiation factor 1A (EIF1A). EIF1A is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.^[1]

[edit] References

^ ^a ^b Entrez Gene: EIF1AY eukaryotic translation initiation factor 1A, Y-linked.

[edit] Further reading

Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-specific gene duplication and loss in human and great ape evolution.". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMID 15252450.
Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.". Mol. Biol. Evol. 21 (2): 384-96. doi:10.1093/molbev/msh027. PMID 14660691.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.". Nature 423 (6942): 825-37. doi:10.1038/nature01722. PMID 12815422.
Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535-40. doi:10.1073/pnas.0437845100. PMID 12569173.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lahn BT, Page DC (1997). "Functional coherence of the human Y chromosome.". Science 278 (5338): 675-80. PMID 9381176.