EHD1

From Wikipedia, the free encyclopedia

EH-domain containing 1

Identifiers

EHD1; FLJ42622; FLJ44618; H-PAST; HPAST1; PAST; PAST1

External IDs

OMIM: 605888 MGI: 1341878 HomoloGene: 81678

Gene ontology
Molecular Function:	• nucleotide binding • molecular_function • GTPase activity • calcium ion binding • protein binding • ATP binding • GTP binding
Cellular Component:	• cellular_component • early endosome • plasma membrane • endocytic vesicle
Biological Process:	• endocytosis • biological_process • endosome transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006795 (mRNA)
NP_006786 (protein)

NM_010119 (mRNA)
NP_034249 (protein)

Location

Chr 11: 64.38 - 64.4 Mb

Chr 19: 6.28 - 6.3 Mb

Pubmed search

[1]

[2]

EH-domain containing 1, also known as EHD1, is a human gene.^[1]

This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors.^[1]

[edit] References

^ ^a ^b Entrez Gene: EHD1 EH-domain containing 1.

[edit] Further reading

Di Fiore PP, Pelicci PG, Sorkin A (1998). "EH: a novel protein-protein interaction domain potentially involved in intracellular sorting.". Trends Biochem. Sci. 22 (11): 411–3. PMID 9397678.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Guru SC, Agarwal SK, Manickam P, et al. (1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.". Genome Res. 7 (7): 725–35. PMID 9253601.
Mintz L, Galperin E, Pasmanik-Chor M, et al. (1999). "EHD1--an EH-domain-containing protein with a specific expression pattern.". Genomics 59 (1): 66–76. doi:10.1006/geno.1999.5800. PMID 10395801.
Haider NB, Searby C, Galperin E, et al. (2000). "Evaluation and molecular characterization of EHD1, a candidate gene for Bardet-Biedl syndrome 1 (BBS1).". Gene 240 (1): 227–32. PMID 10564830.
Pohl U, Smith JS, Tachibana I, et al. (2000). "EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.". Genomics 63 (2): 255–62. doi:10.1006/geno.1999.6087. PMID 10673336.
Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.". J. Biol. Chem. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. PMID 11423532.
Caplan S, Naslavsky N, Hartnell LM, et al. (2002). "A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane.". EMBO J. 21 (11): 2557–67. doi:10.1093/emboj/21.11.2557. PMID 12032069.
Galperin E, Benjamin S, Rapaport D, et al. (2003). "EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.". Traffic 3 (8): 575–89. PMID 12121420.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Naslavsky N, Boehm M, Backlund PS, Caplan S (2005). "Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane.". Mol. Biol. Cell 15 (5): 2410–22. doi:10.1091/mbc.E03-10-0733. PMID 15020713.
Guilherme A, Soriano NA, Furcinitti PS, Czech MP (2004). "Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes.". J. Biol. Chem. 279 (38): 40062–75. doi:10.1074/jbc.M401918200. PMID 15247266.
Xu Y, Shi H, Wei S, et al. (2005). "Mutually exclusive interactions of EHD1 with GS32 and syndapin II.". Mol. Membr. Biol. 21 (4): 269–77. doi:10.1080/09687680410001716871. PMID 15371016.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lee DW, Zhao X, Scarselletta S, et al. (2005). "ATP binding regulates oligomerization and endosome association of RME-1 family proteins.". J. Biol. Chem. 280 (17): 17213–20. doi:10.1074/jbc.M412751200. PMID 15710626.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.