EDEM3

From Wikipedia, the free encyclopedia

ER degradation enhancer, mannosidase alpha-like 3

Identifiers

EDEM3; C1orf22

External IDs

OMIM: 610214 MGI: 1914217 HomoloGene: 11866

Gene ontology
Molecular Function:	• mannosyl-oligosaccharide 1,2-alpha-mannosidase activity • calcium ion binding • peptidase activity
Cellular Component:	• endoplasmic reticulum • membrane
Biological Process:	• proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_025191 (mRNA)
NP_079467 (protein)

XM_001003445 (mRNA)
XP_001003445 (protein)

Location

Chr 1: 182.93 - 182.99 Mb

Chr 1: 153.54 - 153.58 Mb

Pubmed search

[1]

[2]

ER degradation enhancer, mannosidase alpha-like 3, also known as EDEM3, is a human gene.^[1]

[edit] References

^ Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.". Genomics 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mast SW, Diekman K, Karaveg K, et al. (2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.". Glycobiology 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
Olivari S, Galli C, Alanen H, et al. (2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation.". J. Biol. Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Hirao K, Natsuka Y, Tamura T, et al. (2006). "EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming.". J. Biol. Chem. 281 (14): 9650–8. doi:10.1074/jbc.M512191200. PMID 16431915.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.