ECT2

From Wikipedia, the free encyclopedia

Epithelial cell transforming sequence 2 oncogene

PDB rendering based on 2cou.

Available structures: 2cou

Identifiers

Symbol(s)

ECT2; FLJ10461; MGC138291

External IDs

OMIM: 600586 MGI: 95281 HomoloGene: 7298

Gene ontology
Molecular Function:	• signal transducer activity • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • protein binding
Cellular Component:	• intracellular
Biological Process:	• intracellular signaling cascade • regulation of Rho protein signal transduction • positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018098 (mRNA)
NP_060568 (protein)

NM_007900 (mRNA)
NP_031926 (protein)

Location

Chr 3: 173.95 - 174.02 Mb

Chr 3: 27.29 - 27.34 Mb

Pubmed search

[1]

[2]

Epithelial cell transforming sequence 2 oncogene, also known as ECT2, is a human gene.^[1]

The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: ECT2 epithelial cell transforming sequence 2 oncogene.

[edit] Further reading

Takai S, Long JE, Yamada K, Miki T (1995). "Chromosomal localization of the human ECT2 proto-oncogene to 3q26.1-->q26.2 by somatic cell analysis and fluorescence in situ hybridization.". Genomics 27 (1): 220-2. doi:10.1006/geno.1995.1033. PMID 7665179.
Miki T, Smith CL, Long JE, et al. (1993). "Oncogene ect2 is related to regulators of small GTP-binding proteins.". Nature 362 (6419): 462-5. doi:10.1038/362462a0. PMID 8464478.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807-28. PMID 8889549.
Tatsumoto T, Xie X, Blumenthal R, et al. (1999). "Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.". J. Cell Biol. 147 (5): 921-8. PMID 10579713.
Kimura K, Tsuji T, Takada Y, et al. (2000). "Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation.". J. Biol. Chem. 275 (23): 17233-6. doi:10.1074/jbc.C000212200. PMID 10837491.
Wennerberg K, Ellerbroek SM, Liu RY, et al. (2003). "RhoG signals in parallel with Rac1 and Cdc42.". J. Biol. Chem. 277 (49): 47810-7. doi:10.1074/jbc.M203816200. PMID 12376551.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307-18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Saito S, Tatsumoto T, Lorenzi MV, et al. (2004). "Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains.". J. Cell. Biochem. 90 (4): 819-36. doi:10.1002/jcb.10688. PMID 14587037.
Hara T, Ishida H, Raziuddin R, et al. (2004). "Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells.". Mol. Biol. Cell 15 (3): 1172-84. doi:10.1091/mbc.E03-07-0531. PMID 14668487.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Liu XF, Ishida H, Raziuddin R, Miki T (2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity.". Mol. Cell. Biol. 24 (15): 6665-75. doi:10.1128/MCB.24.15.6665-6675.2004. PMID 15254234.
Kim JE, Billadeau DD, Chen J (2005). "The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.". J. Biol. Chem. 280 (7): 5733-9. doi:10.1074/jbc.M409298200. PMID 15545273.
Oceguera-Yanez F, Kimura K, Yasuda S, et al. (2005). "Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.". J. Cell Biol. 168 (2): 221-32. doi:10.1083/jcb.200408085. PMID 15642749.
Yüce O, Piekny A, Glotzer M (2007). "An ECT2-centralspindlin complex regulates the localization and function of RhoA.". J. Cell Biol. 170 (4): 571-82. doi:10.1083/jcb.200501097. PMID 16103226.
Niiya F, Xie X, Lee KS, et al. (2006). "Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.". J. Biol. Chem. 280 (43): 36502-9. doi:10.1074/jbc.M508007200. PMID 16118207.
Zhao WM, Fang G (2005). "MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.". Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13158-63. doi:10.1073/pnas.0504145102. PMID 16129829.
Hara T, Abe M, Inoue H, et al. (2006). "Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase.". Oncogene 25 (4): 566-78. doi:10.1038/sj.onc.1209078. PMID 16170345.
Niiya F, Tatsumoto T, Lee KS, Miki T (2006). "Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.". Oncogene 25 (6): 827-37. doi:10.1038/sj.onc.1209124. PMID 16247472.
Nishimura Y, Yonemura S (2006). "Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis.". J. Cell. Sci. 119 (Pt 1): 104-14. doi:10.1242/jcs.02737. PMID 16352658.