EBF1

From Wikipedia, the free encyclopedia

Early B-cell factor 1

Identifiers

EBF1; COE1; EBF; O/E-1; OLF1

External IDs

OMIM: 164343 MGI: 95275 HomoloGene: 7297

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • positive regulation of transcription

Orthologs

Human

Mouse

Refseq

NM_024007 (mRNA)
NP_076870 (protein)

XM_977520 (mRNA)
XP_982614 (protein)

Location

Chr 5: 158.06 - 158.46 Mb

Chr 11: 44.46 - 44.85 Mb

Pubmed search

[1]

[2]

Early B-cell factor 1, also known as EBF1, is a human gene.^[1]

[edit] References

^ Entrez Gene: EBF1 early B-cell factor 1.

[edit] Further reading

Liberg D, Sigvardsson M, Akerblad P (2003). "The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers.". Mol. Cell. Biol. 22 (24): 8389-97. PMID 12446759.
Hagman J, Gutch MJ, Lin H, Grosschedl R (1995). "EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains.". EMBO J. 14 (12): 2907-16. PMID 7796816.
Milatovich A, Qiu RG, Grosschedl R, Francke U (1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11.". Mamm. Genome 5 (4): 211-5. PMID 8012110.
Wang MM, Reed RR (1993). "Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast.". Nature 364 (6433): 121-6. doi:10.1038/364121a0. PMID 8321284.
Hagman J, Belanger C, Travis A, et al. (1993). "Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression.". Genes Dev. 7 (5): 760-73. PMID 8491377.
Travis A, Hagman J, Hwang L, Grosschedl R (1993). "Purification of early-B-cell factor and characterization of its DNA-binding specificity.". Mol. Cell. Biol. 13 (6): 3392-400. PMID 8497258.
Tsai RY, Reed RR (1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development.". J. Neurosci. 17 (11): 4159-69. PMID 9151733.
Gisler R, Jacobsen SE, Sigvardsson M (2000). "Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse.". Blood 96 (4): 1457-64. PMID 10942392.
Gisler R, Sigvardsson M (2002). "The human V-preB promoter is a target for coordinated activation by early B cell factor and E47.". J. Immunol. 168 (10): 5130-8. PMID 11994467.
Smith EM, Gisler R, Sigvardsson M (2002). "Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression.". J. Immunol. 169 (1): 261-70. PMID 12077253.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhao F, McCarrick-Walmsley R, Akerblad P, et al. (2003). "Inhibition of p300/CBP by early B-cell factor.". Mol. Cell. Biol. 23 (11): 3837-46. PMID 12748286.
Merluzzi S, Moretti M, Altamura S, et al. (2004). "CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism.". J. Biol. Chem. 279 (3): 1777-86. doi:10.1074/jbc.M305418200. PMID 14594818.
Bond HM, Mesuraca M, Carbone E, et al. (2004). "Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.". Blood 103 (6): 2062-70. doi:10.1182/blood-2003-07-2388. PMID 14630787.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Smith EM, Akerblad P, Kadesch T, et al. (2005). "Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development.". Blood 106 (6): 1995-2001. doi:10.1182/blood-2004-12-4744. PMID 15920012.
Akerblad P, Månsson R, Lagergren A, et al. (2006). "Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics.". Physiol. Genomics 23 (2): 206-16. doi:10.1152/physiolgenomics.00015.2005. PMID 16106032.
Martínez A, Mas A, de las Heras V, et al. (2006). "Early B-cell Factor gene association with multiple sclerosis in the Spanish population.". BMC neurology 5: 19. doi:10.1186/1471-2377-5-19. PMID 16255771.
Roessler S, Györy I, Imhof S, et al. (2007). "Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5.". Mol. Cell. Biol. 27 (2): 579-94. doi:10.1128/MCB.01192-06. PMID 17101802.