DVL3

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Dishevelled, dsh homolog 3 (Drosophila)
PDB rendering based on 1l6o.
Available structures: 1l6o, 2f0a
Identifiers
Symbol(s) DVL3; KIAA0208
External IDs OMIM: 601368 MGI: 108100 HomoloGene: 20928
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1857 13544
Ensembl ENSG00000161202 ENSMUSG00000003233
Uniprot Q92997 Q61062
Refseq NM_004423 (mRNA)
NP_004414 (protein)		 NM_007889 (mRNA)
NP_031915 (protein)
Location Chr 3: 185.36 - 185.37 Mb Chr 16: 20.43 - 20.45 Mb
Pubmed search [1] [2]

Dishevelled, dsh homolog 3 (Drosophila), also known as DVL3, is a human gene.[1]

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.[1]

[edit] References

  1. ^ a b Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila).

[edit] Further reading

  • Pizzuti A, Amati F, Calabrese G, et al. (1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.". Hum. Mol. Genet. 5 (7): 953-8. PMID 8817329. 
  • Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321-9, 341-54. PMID 9039502. 
  • Semënov MV, Snyder M (1997). "Human dishevelled genes constitute a DHR-containing multigene family.". Genomics 42 (2): 302-10. doi:10.1006/geno.1997.4713. PMID 9192851. 
  • Bui TD, Beier DR, Jonssen M, et al. (1997). "cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.". Biochem. Biophys. Res. Commun. 239 (2): 510-6. doi:10.1006/bbrc.1997.7500. PMID 9344861. 
  • Kishida S, Yamamoto H, Hino S, et al. (1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.". Mol. Cell. Biol. 19 (6): 4414-22. PMID 10330181. 
  • Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.". J. Biol. Chem. 275 (31): 23790-7. doi:10.1074/jbc.M909107199. PMID 10806215. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hocevar BA, Mou F, Rennolds JL, et al. (2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2).". EMBO J. 22 (12): 3084-94. doi:10.1093/emboj/cdg286. PMID 12805222. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Torban E, Wang HJ, Groulx N, Gros P (2005). "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.". J. Biol. Chem. 279 (50): 52703-13. doi:10.1074/jbc.M408675200. PMID 15456783. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Chan DW, Chan CY, Yam JW, et al. (2006). "Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer.". Gastroenterology 131 (4): 1218-27. doi:10.1053/j.gastro.2006.07.020. PMID 17030191. 
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