DUSP2

From Wikipedia, the free encyclopedia

Dual specificity phosphatase 2

PDB rendering based on 1m3g.

Available structures: 1m3g

Identifiers

Symbol(s)

DUSP2; PAC1; PAC-1

External IDs

OMIM: 603068 MGI: 101911 HomoloGene: 3255

Gene ontology
Molecular Function:	• protein tyrosine phosphatase activity • protein tyrosine/threonine phosphatase activity • hydrolase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • mitogen-activated protein kinase binding
Cellular Component:	• nucleus
Biological Process:	• inactivation of MAPK activity • protein amino acid dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004418 (mRNA)
NP_004409 (protein)

NM_010090 (mRNA)
NP_034220 (protein)

Location

Chr 2: 96.17 - 96.17 Mb

Chr 2: 127.03 - 127.03 Mb

Pubmed search

[1]

[2]

Dual specificity phosphatase 2, also known as DUSP2, is a human gene.^[1]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.^[1]

[edit] References

^ ^a ^b Entrez Gene: DUSP2 dual specificity phosphatase 2.

[edit] Further reading

Wu J, Jin YJ, Calaf GM, et al. (2007). "PAC1 is a direct transcription target of E2F-1 in apoptotic signaling.". Oncogene 26 (45): 6526-35. doi:10.1038/sj.onc.1210484. PMID 17471234.
Zhang Q, Muller M, Chen CH, et al. (2006). "New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding.". J. Mol. Biol. 354 (4): 777-88. doi:10.1016/j.jmb.2005.10.006. PMID 16288922.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kothapalli R, Yoder SJ, Kusmartseva I, Loughran TP (2004). "Characterization of a variant of PAC-1 in large granular lymphocyte leukemia.". Protein Expr. Purif. 32 (1): 52-60. doi:10.1016/S1046-5928(03)00237-7. PMID 14680939.
Zhang Y, Guan DL, Xia CQ, et al. (2004). "Relationship between the expression levels of CD61, CD63, and PAC-1 on platelet surface in peripheral blood and the transplanted kidney function.". Transplant. Proc. 35 (4): 1360-3. PMID 12826159.
Yin Y, Liu YX, Jin YJ, et al. (2003). "PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression.". Nature 422 (6931): 527-31. doi:10.1038/nature01519. PMID 12673251.
Farooq A, Plotnikova O, Chaturvedi G, et al. (2003). "Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP.". Structure 11 (2): 155-64. PMID 12575935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ward Y, Gupta S, Jensen P, et al. (1994). "Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1.". Nature 367 (6464): 651-4. doi:10.1038/367651a0. PMID 8107850.
Martell KJ, Kwak S, Hakes DJ, et al. (1995). "Chromosomal localization of four human VH1-like protein-tyrosine phosphatases.". Genomics 22 (2): 462-4. doi:10.1006/geno.1994.1411. PMID 7806236.
Rohan PJ, Davis P, Moskaluk CA, et al. (1993). "PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase.". Science 259 (5102): 1763-6. PMID 7681221.
Yi H, Morton CC, Weremowicz S, et al. (1995). "Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11.". Genomics 28 (1): 92-6. doi:10.1006/geno.1995.1110. PMID 7590752.
Raingeaud J, Gupta S, Rogers JS, et al. (1995). "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.". J. Biol. Chem. 270 (13): 7420-6. PMID 7535770.