DSCR2

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Down syndrome critical region gene 2
Identifiers
Symbol(s) DSCR2; PAC1; C21LRP; LRPC21
External IDs OMIM: 605296 MGI: 1860263 HomoloGene: 2759
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8624 56088
Ensembl ENSG00000183527 ENSMUSG00000022913
Uniprot O95456 n/a
Refseq NM_003720 (mRNA)
NP_003711 (protein)		 NM_019537 (mRNA)
NP_062410 (protein)
Location Chr 21: 39.47 - 39.48 Mb Chr 16: 96.08 - 96.1 Mb
Pubmed search [1] [2]

Down syndrome critical region gene 2, also known as DSCR2, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: DSCR2 Down syndrome critical region gene 2.

[edit] Further reading

  • Vidal-Taboada JM, Sanz S, Egeo A, et al. (1998). "Identification and characterization of a new gene from human chromosome 21 between markers D21S343 and D21S268 encoding a leucine-rich protein.". Biochem. Biophys. Res. Commun. 250 (3): 547–54. doi:10.1006/bbrc.1998.9352. PMID 9784380. 
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
  • Vidal-Taboada JM, Lu A, Pique M, et al. (2000). "Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation.". Biochem. Biophys. Res. Commun. 272 (1): 156–63. doi:10.1006/bbrc.2000.2726. PMID 10872820. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Possik PA, Sommer CA, Issa Hori J, et al. (2005). "DSCR2, a Down syndrome critical region protein, is localized to the endoplasmic reticulum of mammalian cells.". European journal of histochemistry : EJH 48 (3): 267–72. PMID 15590417. 
  • Vesa J, Brown Y, Greenfield D, Korenberg JR (2005). "Molecular and cellular characterization of the Down syndrome critical region protein 2.". Biochem. Biophys. Res. Commun. 328 (1): 235–42. doi:10.1016/j.bbrc.2004.09.226. PMID 15670775. 
  • Hirano Y, Hendil KB, Yashiroda H, et al. (2005). "A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.". Nature 437 (7063): 1381–5. doi:10.1038/nature04106. PMID 16251969. 
  • Hirano Y, Hayashi H, Iemura S, et al. (2007). "Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes.". Mol. Cell 24 (6): 977–84. doi:10.1016/j.molcel.2006.11.015. PMID 17189198. 
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