DPYSL2

From Wikipedia, the free encyclopedia

Dihydropyrimidinase-like 2

PDB rendering based on 2gse.

Available structures: 2gse

Identifiers

Symbol(s)

DPYSL2; CRMP2; DHPRP2; DRP-2; DRP2

External IDs

OMIM: 602463 MGI: 1349763 HomoloGene: 74392

Gene ontology
Molecular Function:	• dihydropyrimidinase activity • hydrolase activity
Cellular Component:	• mitochondrion • axon • dendrite • cell soma
Biological Process:	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • signal transduction • nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001386 (mRNA)
NP_001377 (protein)

NM_009955 (mRNA)
NP_034085 (protein)

Location

Chr 8: 26.49 - 26.57 Mb

Chr 14: 65.76 - 65.82 Mb

Pubmed search

[1]

[2]

Dihydropyrimidinase-like 2, also known as DPYSL2, is a human gene.^[1]

[edit] References

^ Entrez Gene: DPYSL2 dihydropyrimidinase-like 2.

[edit] Further reading

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.
Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM (1995). "Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33.". Nature 376 (6540): 509–14. doi:10.1038/376509a0. PMID 7637782.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Roberts RG, Freeman TC, Kendall E, et al. (1996). "Characterization of DRP2, a novel human dystrophin homologue.". Nat. Genet. 13 (2): 223–6. doi:10.1038/ng0696-223. PMID 8640231.
Hamajima N, Matsuda K, Sakata S, et al. (1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.". Gene 180 (1-2): 157–63. PMID 8973361.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Kitamura K, Takayama M, Hamajima N, et al. (2000). "Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene.". DNA Res. 6 (5): 291–7. PMID 10574455.
Gu Y, Hamajima N, Ihara Y (2000). "Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522.". Biochemistry 39 (15): 4267–75. PMID 10757975.
Gu Y, Ihara Y (2000). "Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules.". J. Biol. Chem. 275 (24): 17917–20. doi:10.1074/jbc.C000179200. PMID 10770920.
Arimura N, Inagaki N, Chihara K, et al. (2000). "Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse.". J. Biol. Chem. 275 (31): 23973–80. doi:10.1074/jbc.M001032200. PMID 10818093.
Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family.". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
Santolini E, Puri C, Salcini AE, et al. (2001). "Numb is an endocytic protein.". J. Cell Biol. 151 (6): 1345–52. PMID 11121447.
Lee S, Kim JH, Lee CS, et al. (2002). "Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction.". J. Biol. Chem. 277 (8): 6542–9. doi:10.1074/jbc.M108047200. PMID 11741937.
Weitzdoerfer R, Fountoulakis M, Lubec G (2002). "Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain.". J. Neural Transm. Suppl. (61): 95–107. PMID 11771764.
Fukata Y, Itoh TJ, Kimura T, et al. (2002). "CRMP-2 binds to tubulin heterodimers to promote microtubule assembly.". Nat. Cell Biol. 4 (8): 583–91. doi:10.1038/ncb825. PMID 12134159.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Leung T, Ng Y, Cheong A, et al. (2003). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology.". FEBS Lett. 532 (3): 445–9. PMID 12482610.
Nishimura T, Fukata Y, Kato K, et al. (2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.". Nat. Cell Biol. 5 (9): 819–26. doi:10.1038/ncb1039. PMID 12942088.
Nakata K, Ujike H, Tanaka Y, et al. (2003). "No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans.". Neurosci. Lett. 349 (3): 171–4. PMID 12951196.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.