DPT (gene)

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Dermatopontin
Identifiers
Symbol(s) DPT; TRAMP
External IDs OMIM: 125597 MGI: 1928392 HomoloGene: 1458
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1805 56429
Ensembl ENSG00000143196 ENSMUSG00000026574
Uniprot Q07507 Q9QZZ6
Refseq NM_001937 (mRNA)
NP_001928 (protein)		 NM_019759 (mRNA)
NP_062733 (protein)
Location Chr 1: 166.93 - 166.97 Mb Chr 1: 166.63 - 166.66 Mb
Pubmed search [1] [2]

Dermatopontin, also known as DPT, is a human gene.[1]

Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin.[1]

[edit] References

  1. ^ a b Entrez Gene: DPT dermatopontin.

[edit] Further reading

  • Pochampally RR, Ylostalo J, Penfornis P, et al. (2007). "Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor.". J. Bone Miner. Res. 22 (9): 1338–49. doi:10.1359/jbmr.070605. PMID 17547532. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Shaheduzzaman S, Krishnan V, Petrovic A, et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles.". J. Biomed. Sci. 9 (1): 82–96. PMID 11810028. 
  • Kuroda K, Okamoto O, Shinkai H (1999). "Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen.". J. Invest. Dermatol. 112 (5): 706–10. doi:10.1046/j.1523-1747.1999.00563.x. PMID 10233760. 
  • Okamoto O, Fujiwara S, Abe M, Sato Y (1999). "Dermatopontin interacts with transforming growth factor beta and enhances its biological activity.". Biochem. J. 337 ( Pt 3): 537–41. PMID 9895299. 
  • Superti-Furga A, Rocchi M, Schäfer BW, Gitzelmann R (1993). "Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin).". Genomics 17 (2): 463–7. doi:10.1006/geno.1993.1348. PMID 8104875. 
  • Forbes EG, Cronshaw AD, MacBeath JR, Hulmes DJ (1994). "Tyrosine-rich acidic matrix protein (TRAMP) is a tyrosine-sulphated and widely distributed protein of the extracellular matrix.". FEBS Lett. 351 (3): 433–6. PMID 8082810. 
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