Dolichyldiphosphatase

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In enzymology, a dolichyldiphosphatase (EC 3.6.1.43) is an enzyme that catalyzes the chemical reaction

dolichyl diphosphate + H₂O dolichyl phosphate + phosphate

Thus, the two substrates of this enzyme are dolichyl diphosphate and H₂O, whereas its two products are dolichyl phosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dolichyl-diphosphate phosphohydrolase. Other names in common use include dolichol diphosphatase, dolichyl pyrophosphatase, dolichyl pyrophosphate phosphatase, dolichyl diphosphate phosphohydrolase, and Dol-P-P phosphohydrolase. This enzyme participates in n-glycan biosynthesis.

[edit] References

• IUBMB entry for 3.6.1.43
• BRENDA references for 3.6.1.43 (Recommended.)
• PubMed references for 3.6.1.43
• PubMed Central references for 3.6.1.43
• Google Scholar references for 3.6.1.43
• Naumov AV, Shabalin YA, Vagabov VM and Kulaev IS (Moscow). "Two pathways of dephosphorylation of dolichyl diphosphate in yeasts". B Biochemistry: 551–556. 

[edit] External links

The CAS registry number for this enzyme class is 73361-26-9.

• IUBMB entry for 3.6.1.43

• KEGG entry for 3.6.1.43

• BRENDA entry for 3.6.1.43

• NiceZyme view of 3.6.1.43

• EC2PDB: PDB structures for 3.6.1.43

• PRIAM entry for 3.6.1.43

• PUMA2 entry for 3.6.1.43

• IntEnz: Integrated Enzyme entry for 3.6.1.43

• MetaCyc entry for 3.6.1.43

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047874: dolichyldiphosphatase

• AMIGO entry for GO code 0047874: dolichyldiphosphatase