DOCK1

From Wikipedia, the free encyclopedia

Dedicator of cytokinesis 1

Identifiers

DOCK1; DOCK180; ced5

External IDs

OMIM: 601403 MGI: 2429765 HomoloGene: 55575

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • GTPase activator activity • protein binding
Cellular Component:	• cytoplasm • cytoskeleton • membrane
Biological Process:	• phagocytosis, engulfment • apoptosis • signal transduction • integrin-mediated signaling pathway • small GTPase mediated signal transduction • cell migration

Orthologs

Human

Mouse

n/a

Refseq

NM_001380 (mRNA)
NP_001371 (protein)

NM_001033420 (mRNA)
NP_001028592 (protein)

Location

Chr 10: 128.58 - 129.14 Mb

Chr 7: 134.56 - 135.01 Mb

Pubmed search

[1]

[2]

Dedicator of cytokinesis 1, also known as DOCK1, is a human gene.^[1]

This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis.^[1]

[edit] References

^ ^a ^b Entrez Gene: DOCK1 dedicator of cytokinesis 1.

[edit] Further reading

Hasegawa H, Kiyokawa E, Tanaka S, et al. (1996). "DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.". Mol. Cell. Biol. 16 (4): 1770-6. PMID 8657152.
Takai S, Hasegawa H, Kiyokawa E, et al. (1996). "Chromosomal mapping of the gene encoding DOCK180, a major Crk-binding protein, to 10q26.13-q26.3 by fluorescence in situ hybridization.". Genomics 35 (2): 403-4. doi:10.1006/geno.1996.0378. PMID 8661160.
Matsuda M, Ota S, Tanimura R, et al. (1996). "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.". J. Biol. Chem. 271 (24): 14468-72. PMID 8662907.
Savill J (1998). "Apoptosis. Phagocytic docking without shocking.". Nature 392 (6675): 442-3. doi:10.1038/33025. PMID 9548247.
Wu YC, Horvitz HR (1998). "C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180.". Nature 392 (6675): 501-4. doi:10.1038/33163. PMID 9548255.
Kiyokawa E, Hashimoto Y, Kobayashi S, et al. (1998). "Activation of Rac1 by a Crk SH3-binding protein, DOCK180.". Genes Dev. 12 (21): 3331-6. PMID 9808620.
Albert ML, Kim JI, Birge RB (2001). "alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells.". Nat. Cell Biol. 2 (12): 899-905. doi:10.1038/35046549. PMID 11146654.
Kobayashi S, Shirai T, Kiyokawa E, et al. (2001). "Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3.". Biochem. J. 354 (Pt 1): 73-8. PMID 11171081.
Tu Y, Kucik DF, Wu C (2001). "Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.". FEBS Lett. 491 (3): 193-9. PMID 11240126.
Gu J, Sumida Y, Sanzen N, Sekiguchi K (2001). "Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway.". J. Biol. Chem. 276 (29): 27090-7. doi:10.1074/jbc.M102284200. PMID 11369773.
Gumienny TL, Brugnera E, Tosello-Trampont AC, et al. (2001). "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.". Cell 107 (1): 27-41. PMID 11595183.
Zhou Z, Caron E, Hartwieg E, et al. (2001). "The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.". Dev. Cell 1 (4): 477-89. PMID 11703939.
Worby CA, Simonson-Leff N, Clemens JC, et al. (2002). "Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance.". J. Biol. Chem. 277 (11): 9422-8. doi:10.1074/jbc.M110172200. PMID 11773052.
Brugnera E, Haney L, Grimsley C, et al. (2002). "Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.". Nat. Cell Biol. 4 (8): 574-82. doi:10.1038/ncb824. PMID 12134158.
Côté JF, Vuori K (2003). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.". J. Cell. Sci. 115 (Pt 24): 4901-13. PMID 12432077.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hsia DA, Mitra SK, Hauck CR, et al. (2003). "Differential regulation of cell motility and invasion by FAK.". J. Cell Biol. 160 (5): 753-67. doi:10.1083/jcb.200212114. PMID 12615911.
Katoh H, Negishi M (2003). "RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.". Nature 424 (6947): 461-4. doi:10.1038/nature01817. PMID 12879077.
Grimsley CM, Kinchen JM, Tosello-Trampont AC, et al. (2004). "Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.". J. Biol. Chem. 279 (7): 6087-97. doi:10.1074/jbc.M307087200. PMID 14638695.
Wang X, Wu YC, Fadok VA, et al. (2003). "Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.". Science 302 (5650): 1563-6. doi:10.1126/science.1087641. PMID 14645848.