DNPEP

From Wikipedia, the free encyclopedia

Aspartyl aminopeptidase

Identifiers

DNPEP; DAP; ASPEP

External IDs

Gene ontology
Molecular Function:	• aminopeptidase I activity • metallopeptidase activity • zinc ion binding • aspartyl aminopeptidase activity • metal ion binding
Cellular Component:	• cytoplasm • vacuole
Biological Process:	• proteolysis • peptide metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012100 (mRNA)
NP_036232 (protein)

NM_016878 (mRNA)
NP_058574 (protein)

Location

Chr 2: 219.95 - 219.96 Mb

Chr 1: 75.19 - 75.2 Mb

Pubmed search

[1]

[2]

Aspartyl aminopeptidase, also known as DNPEP, is a human gene.^[1]

The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: DNPEP aspartyl aminopeptidase.

[edit] Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Prieto I, Hermoso F, Gasparo M, et al. (2004). "Angiotensinase activities in the kidney of renovascular hypertensive rats.". Peptides 24 (5): 755–60. PMID 12895663.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wilk S, Wilk E, Magnusson RP (2002). "Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase.". Arch. Biochem. Biophys. 407 (2): 176–83. PMID 12413488.
Wilk S, Wilk E, Magnusson RP (1998). "Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase.". J. Biol. Chem. 273 (26): 15961–70. PMID 9632644.